This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MyBioSource
product type :
ELISA/assay
product name :
Human 1-phosphatidylinositol-4, 5-bisphosphate phosphodiesterase delta-3, PLCD3 ELISA Kit
catalog :
MBS2602805
quantity :
96 Strip Wells
price :
420 USD
product information
catalog number :
MBS2602805
products type :
ELISA Kit
products full name :
Human 1-phosphatidylinositol-4, 5-bisphosphate phosphodiesterase delta-3, PLCD3 ELISA Kit
products short name :
phospholipase C, delta 3
other names :
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3; PLC delta3; phosphoinositide phospholipase C-delta-3; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-3; phospholipase C, delta 3; Phosphoinositide phospholipase C-delta-3; Phospholipase C-delta-3; PLC-delta-3
other gene names :
PLCD3; PLCD3; PLC-delta-3; KIAA1964; PLC-delta-3
uniprot entry name :
PLCD3_HUMAN
reactivity :
Human
storage stability :
Store all reagents at 2-8 degree C.
ncbi gi num :
19115964
ncbi acc num :
NP_588614.1
ncbi gb acc num :
NM_133373.4
uniprot acc num :
Q8N3E9
ncbi mol weight :
89,258 Da
ncbi pathways :
Calcium Signaling Pathway 83050!!Calcium Signaling Pathway 459!!D-myo-inositol (1,4,5)-trisphosphate Biosynthesis Pathway 545326!!D-myo-inositol-5-phosphate Metabolism Pathway 545315!!Inositol Phosphate Metabolism Pathway 82987!!Inositol Phosphate Metabolism Pathway 362!!Inositol Phosphate Metabolism, PI= PIP2 = Ins(1,4,5)P3 = Ins(1,3,4,5)P4 Pathway 413400!!Inositol Phosphate Metabolism, PI= PIP2 = Ins(1,4,5)P3 = Ins(1,3,4,5)P4 Pathway 468323!!Phosphatidylinositol Signaling System Pathway 83052!!Phosphatidylinositol Signaling System Pathway 461
ncbi summary :
This gene encodes a member of the phospholipase C family, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate the second messengers diacylglycerol and inositol 1,4,5-trisphosphate (IP3). Diacylglycerol and IP3 mediate a variety of cellular responses to extracellular stimuli by inducing protein kinase C and increasing cytosolic Ca(2+) concentrations. This enzyme localizes to the plasma membrane and requires calcium for activation. Its activity is inhibited by spermine, sphingosine, and several phospholipids. [provided by RefSeq, Jul 2008]
uniprot summary :
Function: Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca2+ from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow. Catalytic activity: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.1 PublicationManual assertion based on experiment in:Ref.9. Cofactor: Binds 3 calcium ions per subunit. Two of the calcium ions are bound to the C2 domain Inferred.1 PublicationManual assertion based on experiment in:Ref.7. Enzyme regulation: Strongly activated by phosphatidic acid. Inhibited by phosphatidylethanolamine (PtdEtn), phosphatidylcholine (PtdCho), sphingomyelin and phosphatidylserine (PtdSer).2 PublicationsManual assertion based on experiment in:Ref.7
size :
96 Strip Wells
price :
420 USD
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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