Human voltage-gated potassium channel (VGKC) ELISA Kit | MyBioSource MBS2602801 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human voltage-gated potassium channel (VGKC) ELISA Kit

catalog :

MBS2602801

quantity :

48-Strip-Wells

price :

275 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS2602801

products type :

ELISA Kit

products full name :

Human voltage-gated potassium channel (VGKC) ELISA Kit

products short name :

voltage-gated potassium channel (VGKC)

other names :

voltage gated potassium channel; Potassium voltage-gated channel subfamily KQT member 1; potassium voltage-gated channel subfamily KQT member 1; slow delayed rectifier channel subunit; voltage-gated potassium channel subunit Kv7.1; kidney and cardiac voltage dependend K+ channel; IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1; potassium voltage-gated channel, KQT-like subfamily, member 1; IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1; KQT-like 1; Voltage-gated potassium channel subunit Kv7.1

other gene names :

KCNQ1; KCNQ1; LQT; RWS; WRS; LQT1; SQT2; ATFB1; ATFB3; JLNS1; KCNA8; KCNA9; Kv1.9; Kv7.1; KVLQT1; KCNA8; KCNA9; KVLQT1

uniprot entry name :

KCNQ1_HUMAN

reactivity :

Human

specificity :

No cross-reaction with other factors.

storage stability :

Store all reagents at 2-8 degree C.

other info1 :

Samples: Human serum, plasma or cell culture supernatant and organizations in the natural and recombinant VGKC concentration. Assay Type: Sandwich. Detection Range: 20 ng/ml-0.312 ng/ml. Sensitivity: 0.06 ng/ml.

other info2 :

Intra-assay Precision: <= 8%. Inter-assay Precision: <= 12%

products description :

Principle of the Assay This experiment use double-sandwich elisa technique and the ELISA Kit provided is typical. The pre-coated antibody is human VGKC monoclonal antibody and the detecting antibody is polyclonal antibody with biotin labeled. Samples and biotin labeling antibody are added into ELISA plate wells and washed out with PBS or TBS. Then Avidin-peroxidase conjugates are added to ELISA wells in order; Use TMB substrate for coloring after reactant thoroughly washed out by PBS or TBS. TMB turns into blue in peroxidase catalytic and finally turns into yellow under the action of acid. The color depth and the testing factors in samples are positively correlated.

ncbi gi num :

2465515

ncbi acc num :

AAC51781.1

uniprot acc num :

P51787

ncbi mol weight :

74,699 Da

ncbi pathways :

Cholinergic Synapse Pathway (217716); Gastric Acid Secretion Pathway (154409); Gastric Acid Secretion Pathway (154383); Neuronal System Pathway (106513); Pancreatic Secretion Pathway (169306); Pancreatic Secretion Pathway (169295); Potassium Channels Pathway (366221); Protein Digestion And Absorption Pathway (172847); Protein Digestion And Absorption Pathway (171868); SIDS Susceptibility Pathways (198901)

ncbi summary :

This gene encodes a voltage-gated potassium channel required for repolarization phase of the cardiac action potential. This protein can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. Mutations in this gene are associated with hereditary long QT syndrome 1 (also known as Romano-Ward syndrome), Jervell and Lange-Nielsen syndrome, and familial atrial fibrillation. This gene exhibits tissue-specific imprinting, with preferential expression from the maternal allele in some tissues, and biallelic expression in others. This gene is located in a region of chromosome 11 amongst other imprinted genes that are associated with Beckwith-Wiedemann syndrome (BWS), and itself has been shown to be disrupted by chromosomal rearrangements in patients with BWS. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2011]

uniprot summary :

Kv7.1: a voltage-gated potassium channel protein required for the repolarization phase of the cardiac action potential. Associates with KCNE1 (MinK) to form the I(Ks) cardiac potassium current. Elicits a rapidly activating, potassium-selective outward current. May associate also with KCNE3 (MiRP2) to form the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions, which is reduced in cystic fibrosis and pathologically stimulated in cholera and other forms of secretory diarrhea. Abundantly expressed in heart, pancreas, prostate, kidney, small intestine and peripheral blood leukocytes. Less abundant in placenta, lung, spleen, colon, thymus, testis and ovaries. Three alternatively spliced isoforms have been described. Protein type: Membrane protein, multi-pass; Channel, potassium; Membrane protein, integral. Chromosomal Location of Human Ortholog: 11p15.5. Cellular Component: voltage-gated potassium channel complex; cytoplasmic vesicle membrane; basolateral plasma membrane; lysosome; early endosome; late endosome; plasma membrane. Molecular Function: calmodulin binding; voltage-gated potassium channel activity; protein binding; delayed rectifier potassium channel activity; protein phosphatase 1 binding. Biological Process: synaptic transmission; genetic imprinting; sensory perception of sound; positive regulation of heart rate; gene silencing; regulation of heart contraction; cardiac muscle contraction. Disease: Jervell And Lange-nielsen Syndrome 1; Beckwith-wiedemann Syndrome; Atrial Fibrillation, Familial, 3; Short Qt Syndrome 2; Long Qt Syndrome 1

size1 :

48-Strip-Wells

price1 :

275 USD

size2 :

96-Strip-Wells

price2 :

420

more info or order :

MyBioSource product webpage