product summary
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company name :
MyBioSource
product type :
ELISA/assay
product name :
Human Geminin, GMNN ELISA Kit
catalog :
MBS2602751
quantity :
48-Strip-Wells
price :
275 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS2602751
products type :
ELISA Kit
products full name :
Human Geminin, GMNN ELISA Kit
products short name :
Geminin, GMNN
other names :
geminin; Geminin; geminin; geminin, DNA replication inhibitor
products gene name :
GMNN
other gene names :
GMNN; GMNN; Gem
uniprot entry name :
GEMI_HUMAN
reactivity :
Human
storage stability :
Store all reagents at 2-8 degree C.
ncbi gi num :
354681980
ncbi acc num :
NP_001238918.1
ncbi gb acc num :
NM_001251989.1
uniprot acc num :
O75496
ncbi mol weight :
23,565 Da
ncbi pathways :
Assembly Of The Pre-replicative Complex Pathway (105821); Association Of Licensing Factors With The Pre-replicative Complex Pathway (105900); CDT1 Association With The CDC6:ORC:origin Complex Pathway (105824); Cell Cycle Pathway (530733); Cell Cycle, Mitotic Pathway (105765); DNA Replication Pathway (198771); DNA Replication Pathway (105897); DNA Replication Pre-Initiation Pathway (105898); M/G1 Transition Pathway (105820); Regulation Of DNA Replication Pathway (105899)
ncbi summary :
This gene encodes a protein that plays a critical role in cell cycle regulation. The encoded protein inhibits DNA replication by binding to DNA replication factor Cdt1, preventing the incorporation of minichromosome maintenance proteins into the pre-replication complex. The encoded protein is expressed during the S and G2 phases of the cell cycle and is degraded by the anaphase-promoting complex during the metaphase-anaphase transition. Increased expression of this gene may play a role in several malignancies including colon, rectal and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and two pseudogenes of this gene are located on the short arm of chromosome 16. [provided by RefSeq, Oct 2011]
uniprot summary :
Geminin: Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC). It is degraded during the mitotic phase of the cell cycle. Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle. Homotetramer. Interacts with CDT1; inhibits binding of the MCM complex to origins of replication. Interacts with IDAS; targets GMNN to the nucleus, prevents GMNN interaction with CDT1 and competes with IDAS homodimerization. Belongs to the geminin family. Protein type: Motility/polarity/chemotaxis; Cell cycle regulation. Chromosomal Location of Human Ortholog: 6p22.3. Cellular Component: nucleoplasm; cytoplasm; cytosol; nucleus. Molecular Function: protein binding; histone deacetylase binding; transcription corepressor activity. Biological Process: organ morphogenesis; negative regulation of DNA replication; protein complex assembly; mitotic cell cycle; negative regulation of transcription, DNA-dependent; negative regulation of cell cycle
size1 :
48-Strip-Wells
price1 :
275 USD
size2 :
96-Strip-Wells
price2 :
420
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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