catalog number :
MBS2602685
products type :
ELISA Kit
products full name :
Human Fas apoptotic inhibitory molecule 2, FAIM2 ELISA Kit
products short name :
Fas apoptotic inhibitory molecule 2, FAIM2
other names :
protein lifeguard 2; Protein lifeguard 2; protein lifeguard 2; neural membrane protein 35; transmembrane BAX inhibitor motif-containing protein 2; Fas apoptotic inhibitory molecule 2; Fas apoptotic inhibitory molecule 2; Neural membrane protein 35; Transmembrane BAX inhibitor motif-containing protein 2
products gene name :
FAIM2
other gene names :
FAIM2; FAIM2; LFG; LFG2; NGP35; NMP35; TMBIM2; KIAA0950; LFG; LFG2; NMP35; TMBIM2
uniprot entry name :
LFG2_HUMAN
specificity :
No cross-reaction with other factors.
storage stability :
Store all reagents at 2-8 degree C.
other info1 :
Samples: Human serum, plasma or cell culture supernatant and organizations in the natural and recombinant FAIM2 concentration. Assay Type: Sandwich. Detection Range: 20 ng/ml-0.312 ng/ml. Sensitivity: 0.06 ng/ml.
other info2 :
Intra-assay Precision: <= 8%. Inter-assay Precision: <= 12%
products description :
Principle of the Assay This experiment use double-sandwich elisa technique and the ELISA Kit provided is typical. The pre-coated antibody is human FAIM2 monoclonal antibody and the detecting antibody is polyclonal antibody with biotin labeled. Samples and biotin labeling antibody are added into ELISA plate wells and washed out with PBS or TBS. Then Avidin-peroxidase conjugates are added to ELISA wells in order; Use TMB substrate for coloring after reactant thoroughly washed out by PBS or TBS. TMB turns into blue in peroxidase catalytic and finally turns into yellow under the action of acid. The color depth and the testing factors in samples are positively correlated.
ncbi acc num :
NP_036438.2
ncbi gb acc num :
NM_012306.3
ncbi mol weight :
35,110 Da
ncbi pathways :
FAS (CD95) Signaling Pathway (138081)
uniprot summary :
FAIM2: Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development. Belongs to the BI1 family. LFG subfamily. Protein type: Apoptosis; Membrane protein, integral; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 12q13. Cellular Component: postsynaptic membrane; integral to membrane; cell junction; lipid raft. Biological Process: cerebellar granular layer development; apoptosis; regulation of neuron apoptosis; cerebellar Purkinje cell differentiation; cerebellar Purkinje cell layer development; cerebellum development; negative regulation of neuron apoptosis; negative regulation of apoptosis