Human Amiloride-sensitive Cation channel 1, neuronal, ACCN1 ELISA Kit | MyBioSource MBS2602669 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Amiloride-sensitive Cation channel 1, neuronal, ACCN1 ELISA Kit

catalog :

MBS2602669

quantity :

48-Strip-Wells

price :

275 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS2602669

products type :

ELISA Kit

products full name :

Human Amiloride-sensitive Cation channel 1, neuronal, ACCN1 ELISA Kit

products short name :

Amiloride-sensitive Cation channel 1, neuronal, ACCN1

other names :

acid-sensing ion channel 2 isoform MDEG1; Acid-sensing ion channel 2; acid-sensing ion channel 2; brain sodium channel 1; mammalian degenerin homolog; neuronal amiloride-sensitive cation channel 1; amiloride-sensitive cation channel 1, neuronal; acid-sensing (proton-gated) ion channel 2; Amiloride-sensitive brain sodium channel; Amiloride-sensitive cation channel 1, neuronal; Amiloride-sensitive cation channel neuronal 1; Brain sodium channel 1; BNC1; BNaC1; Mammalian degenerin homolog

products gene name :

ACCN1

other gene names :

ASIC2; ASIC2; ACCN; BNC1; MDEG; ACCN1; BNaC1; ASIC2a; hBNaC1; ACCN; ACCN1; BNAC1; MDEG; ASIC2; BNC1; BNaC1

uniprot entry name :

ASIC2_HUMAN

reactivity :

Human

specificity :

No cross-reaction with other factors.

storage stability :

Store all reagents at 2-8 degree C.

other info1 :

Samples: Human serum, plasma or Cell Culture Supernatant and organizations in the natural and recombinant ACCN1 concentration. Assay Type: Sandwich. Detection Range: 100 ng/ml-1.56 ng/ml. Sensitivity: 0.5 ng/ml.

other info2 :

Intra-assay Precision: <= 8%. Inter-assay Precision: <= 12%

products description :

Priciple of the assay: This experiment use double-sandwich elisa technique and the ELISA Kit provided is typical. The pre-coated antibody is human ACCN1 monoclonal antibody and the detecting antibody is polyclonal antibody with biotin labeled. Samples and biotin labeling antibody are added into ELISA plate wells and washed out with PBS or TBS. Then Avidin-peroxidase conjugates are added to ELISA wells in order; Use TMB substrate for coloring after reactant thoroughly washed out by PBS or TBS. TMB turns into blue in peroxidase catalytic and finally turns into yellow under the action of acid. The color depth and the testing factors in samples are positively correlated.

ncbi gi num :

9998944

ncbi acc num :

NP_001085.2

ncbi gb acc num :

NM_001094.4

uniprot acc num :

Q16515

ncbi mol weight :

57,709 Da

ncbi pathways :

Taste Transduction Pathway (83088); Taste Transduction Pathway (499)

ncbi summary :

This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene may play a role in neurotransmission. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 3 has been observed to co-assemble into proton-gated channels sensitive to gadolinium. Alternative splicing has been observed at this locus and two variants, encoding distinct isoforms, have been identified. [provided by RefSeq, Feb 2012]

uniprot summary :

ASIC2: Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC2 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Channel, cation; Apoptosis; Transporter, ion channel; Transporter; Membrane protein, multi-pass; Membrane protein, integral. Chromosomal Location of Human Ortholog: 17q12. Cellular Component: cell soma; integral to plasma membrane; dendritic spine; plasma membrane; synapse. Molecular Function: amiloride-sensitive sodium channel activity; protein binding; ion gated channel activity; voltage-gated sodium channel activity. Biological Process: central nervous system development; regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback; monovalent inorganic cation transport; sensory perception of sour taste; detection of mechanical stimulus involved in sensory perception; peripheral nervous system development; synaptic transmission; positive regulation of synaptogenesis; regulation of membrane potential; sensory perception of sound; regulation of gene expression; regulation of vasoconstriction; regulation of blood coagulation; phototransduction; transmembrane transport; negative regulation of apoptosis

size1 :

48-Strip-Wells

price1 :

275 USD

size2 :

96-Strip-Wells

price2 :

420

more info or order :

MyBioSource product webpage