Human alpha-Synuclein, alpha-SYN ELISA Kit | MyBioSource MBS2602614 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human alpha-Synuclein, alpha-SYN ELISA Kit

catalog :

MBS2602614

quantity :

48-Strip-Wells

price :

275 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS2602614

products type :

ELISA Kit

products full name :

Human alpha-Synuclein, alpha-SYN ELISA Kit

products short name :

alpha-Synuclein, alpha-SYN

other names :

alpha-synuclein; Alpha-synuclein; alpha-synuclein; alpha SYN; non-A4 component of amyloid; non-A beta component of AD amyloid; synuclein, alpha; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor

products gene name :

alpha-SYN

other gene names :

Snca; Snca; NACP; alphaSYN; Syn

uniprot entry name :

SYUA_MOUSE

reactivity :

Human

specificity :

No cross-reaction with other factors.

storage stability :

Store all reagents at 2-8 degree C.

other info1 :

Samples: Human serum, plasma or Cell Culture Supernatant and organizations in the natural and recombinant alpha-SYN concentration. Assay Type: Sandwich. Detection Range: 1000 pg/ml-1.56pg/ml. Sensitivity: 5pg/ml.

other info2 :

Intra-assay Precision: <= 8%. Inter-assay Precision: <= 12%

products description :

Principle of the assay: This experiment use double-sandwich elisa technique and the ELISA Kit provided is typical. The pre-coated antibody is human alpha-SYN monoclonal antibody and the detecting antibody is polyclonal antibody with biotin labeled. Samples and biotin labeling antibody are added into ELISA plate wells and washed out with PBS or TBS. Then Avidin-peroxidase conjugates are added to ELISA wells in order; Use TMB substrate for coloring after reactant thoroughly washed out by PBS or TBS. TMB turns into blue in peroxidase catalytic and finally turns into yellow under the action of acid. The color depth and the testing factors in samples are positively correlated.

ncbi gi num :

109638747

ncbi acc num :

NP_001035916.1

ncbi gb acc num :

NM_001042451.1

uniprot acc num :

O55042

ncbi mol weight :

14,485 Da

ncbi pathways :

Alzheimer's Disease Pathway (83294); Alzheimer's Disease Pathway (509); EGFR1 Signaling Pathway (198278); Parkinson's Disease Pathway (83295)

uniprot summary :

SNCA: a member of the synuclein family. Abundantly expressed in the brain. Inhibits phospholipase D2 selectively. May integrate presynaptic signaling and membrane trafficking. Implicated in the pathogenesis of Parkinson s disease. A major component of amyloid plaques in the brains of patients with Alzheimer s disease. Two alternatively spliced isoforms transcripts have been identified. Protein type: Adaptor/scaffold. Cellular Component: Golgi apparatus; nuclear outer membrane; mitochondrion; terminal button; inclusion body; cytosol; platelet alpha granule membrane; synaptic vesicle; perinuclear region of cytoplasm; cytoplasm; synapse; cytoplasmic vesicle membrane; rough endoplasmic reticulum; intracellular membrane-bound organelle; cell; fibril; cell cortex; actin cytoskeleton; growth cone; cytoskeleton; axon; plasma membrane; ribosome; nerve terminal; nucleus. Molecular Function: identical protein binding; protein domain specific binding; histone binding; zinc ion binding; kinesin binding; ferrous iron binding; microtubule binding; metal ion binding; caspase inhibitor activity; beta-tubulin binding; magnesium ion binding; phosphoprotein binding; protein N-terminus binding; Hsp70 protein binding; oxidoreductase activity; calcium ion binding; arachidonic acid binding; dynein binding; protein binding; enzyme binding; phospholipase binding; copper ion binding; phospholipid binding; tau protein binding; alpha-tubulin binding. Biological Process: regulation of long-term neuronal synaptic plasticity; negative regulation of serotonin uptake; synaptic transmission, dopaminergic; regulation of acyl-CoA biosynthetic process; adult locomotory behavior; mitochondrial membrane organization and biogenesis; negative regulation of norepinephrine uptake; regulation of neurotransmitter secretion; microglial cell activation; positive regulation of endocytosis; response to lipopolysaccharide; negative regulation of monooxygenase activity; dopamine biosynthetic process; negative regulation of caspase activity; fatty acid metabolic process; regulation of dopamine secretion; dopamine metabolic process; positive regulation of neurotransmitter secretion; positive regulation of synaptic transmission; negative regulation of dopamine uptake; negative regulation of histone acetylation; synaptic transmission; response to magnesium ion; negative regulation of exocytosis; negative regulation of protein amino acid phosphorylation; behavioral response to cocaine; receptor internalization; phospholipid metabolic process; regulation of neuron apoptosis; synapse organization and biogenesis; negative regulation of neuron apoptosis; response to iron(II) ion; positive regulation of receptor recycling; caspase activation; response to drug; neutral lipid metabolic process; protein destabilization; negative regulation of microtubule polymerization; regulation of glutamate secretion; regulation of macrophage activation; synaptic vesicle transport; positive regulation of peptidyl-serine phosphorylation; negative regulation of dopamine metabolic process; organelle ATP synthesis coupled electron transport; regulation of locomotion; synaptic vesicle endocytosis; positive regulation of release of sequestered calcium ion into cytosol; regulation of excitatory postsynaptic membrane potential; negative regulation of transporter activity; regulation of neuronal synaptic plasticity; negative regulation of apoptosis

size1 :

48-Strip-Wells

price1 :

275 USD

size2 :

96-Strip-Wells

price2 :

420

more info or order :

MyBioSource product webpage