Recombinant Human T-Cell Surface Glycoprotein CD8 beta Chain Protein | MyBioSource MBS2556682 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human T-Cell Surface Glycoprotein CD8 beta Chain Protein

catalog :

MBS2556682

quantity :

0.01 mg

price :

160 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS2556682

products type :

Recombinant Protein

products full name :

Recombinant Human T-Cell Surface Glycoprotein CD8 beta Chain Protein

products short name :

[T-Cell Surface Glycoprotein CD8 beta Chain]

products name syn :

[T-Cell Surface Glycoprotein CD8 Beta Chain; CD8b; CD8B; CD8B1]

other names :

[T-cell surface glycoprotein CD8 beta chain isoform 6; T-cell surface glycoprotein CD8 beta chain; T-cell surface glycoprotein CD8 beta chain; CD8b molecule; CD_antigen: CD8b]

other gene names :

[CD8B; CD8B; LY3; P37; LEU2; LYT3; CD8B1; CD8B1]

host :

Human Cells

sequence length :

198

purity :

>95% as determined by reducing SDS-PAGE.

form :

Lyophilized from a 0.2 mum filtered solution of 20mM PBS, 150mM NaCl, pH 7.4.

storage stability :

Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. This product is provided as lyophilized powder which is shipped with ice packs.

other info1 :

Species: Human. Endotoxin: <1.0 EU per ug as determined by LAL method.

other info2 :

Fragment: Leu22-Pro170. Fusion Tag: C-6His. Reconstitution: Centrifuge tubes before opening. Do not mix by vortex or pipetting. It is recommended that sterile water (200ul) be added to the vial to prepare a stock solution of 0.25mg/mL. Concentration is measured by UV-Vis.

products description :

T-Cell Surface Glycoprotein CD8beta Chain (CD8 Antigen) is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. CD8 Antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified.

ncbi gi num :

296010933

ncbi acc num :

NP_001171571.1

ncbi gb acc num :

NM_001178100.1

uniprot acc num :

P10966-1

ncbi mol weight :

Molecular Mass: 17.8kDa. Actual Protein Molecular Mass: 25-32kDa

ncbi pathways :

Adaptive Immune System Pathway (366160); Antigen Processing And Presentation Pathway (83074); Antigen Processing And Presentation Pathway (485); Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480); Disease Pathway (530764); Downstream Signaling In Naive CD8+ T Cells Pathway (138018); HIV Infection Pathway (105983); Hematopoietic Cell Lineage Pathway (83078); Hematopoietic Cell Lineage Pathway (489)

ncbi summary :

The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified. [provided by RefSeq, May 2010]

uniprot summary :

Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. A palmitoylation site in the cytoplasmic tail of CD8B chain contributes to partitioning of CD8 into the plasma membrane lipid rafts where signaling proteins are enriched. Once LCK recruited, it initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). Additionally, plays a critical role in thymic selection of CD8+ T-cells.

size1 :

0.01 mg

price1 :

160 USD

size2 :

0.05 mg

price2 :

325

more info or order :

MyBioSource product webpage