catalog number :
MBS2556671
products type :
Recombinant Protein
products full name :
Recombinant Human Cytosolic Sulfotransferase Family 1A Member 3 Protein
products short name :
[Cytosolic Sulfotransferase Family 1A Member 3]
products name syn :
[Sulfotransferase 1A3/1A4; ST1A3/ST1A4; Aryl Sulfotransferase 1A3/1A4; Catecholamine-Sulfating Phenol Sulfotransferase; HAST3; M-PST; Monoamine-Sulfating Phenol Sulfotransferase; Placental Estrogen Sulfotransferase; Sulfotransferase Monoamine-Preferring; Thermolabile Phenol Sulfotransferase; TL-PST; SULT1A3; STM; SULT1A4]
other names :
[sulfotransferase 1A3; sulfotransferase family 1A member 3]
other gene names :
[SULT1A3; STM; HAST; HAST3; M-PST; ST1A3; ST1A4; ST1A5; TL-PST; ST1A3/ST1A4]
purity :
>95% as determined by SDS-PAGE.
form :
Supplied as a 0.2 um filtered solution of 20mM Tris, 100mM NaCl, pH 8.0.
storage stability :
Store at < -20 degree C, stable for 6 months. Please minimize freeze-thaw cycles.
image1 heading :
SDS-Page
other info1 :
Species: Human. Endotoxin: <1.0 EU per ug as determined by LAL test.
other info2 :
Sequence: Met1-Leu295. Fusion Tag: N-6His. Bio Activity: Measured by its ability to transfer sulfate from PAPS to 1-Napthol.The specific activity is > 150 pmoles/min/ug. Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C.
products description :
Sulfotransferase 1A3/1A4 (SULT1A3) is 295 amino acids in length and localizes to the cytoplasm. It is a member of the Sulfotransferase 1 family. SULT1A3 can be found in the liver, colon, kidney, lung, brain, spleen, small intestine, placenta, and leukocytes. SULT1A3 exists as a homodimer and it catalyzes the sulfation of phenolic monoamines, such as dopamine, norepinephrine and serotonin, and phenolic and catecholic drugs.
ncbi mol weight :
Molecular Mass: 35.6kDa. Actual Protein Molecular Mass: 35kDa
ncbi pathways :
Biological Oxidations Pathway (105698); Chemical Carcinogenesis Pathway (673221); Chemical Carcinogenesis Pathway (673237); Cytosolic Sulfonation Of Small Molecules Pathway (105724); Defective AHCY Causes Hypermethioninemia With S-adenosylhomocysteine Hydrolase Deficiency (HMAHCHD) Pathway (1127639); Defective GCLC Causes Hemolytic Anemia Due To Gamma-glutamylcysteine Synthetase Deficiency (HAGGSD) Pathway (1127658); Defective GGT1 Causes Glutathionuria (GLUTH) Pathway (1127659); Defective GSS Causes Glutathione Synthetase Deficiency (GSS Deficiency) Pathway (1127660); Defective MAT1A Causes Methionine Adenosyltransferase Deficiency (MATD) Pathway (1127663); Defective OPLAH Causes 5-oxoprolinase Deficiency (OPLAHD) Pathway (1127661)
ncbi summary :
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a phenol sulfotransferase with thermolabile enzyme activity. Four sulfotransferase genes are located on the p arm of chromosome 16; this gene and SULT1A4 arose from a segmental duplication. This gene is the most centromeric of the four sulfotransferase genes. Read-through transcription exists between this gene and the upstream SLX1A (SLX1 structure-specific endonuclease subunit homolog A) gene that encodes a protein containing GIY-YIG domains. [provided by RefSeq, Nov 2010]