antibody

IL17A Polyclonal Antibody

MBS2556071

0.06 mL

150 USD

polyclonal

rabbit

nonconjugated

mouse, rat

Antibody

IL17A Polyclonal Antibody

[IL17A]

[CTLA 8; CTLA-8; CTLA8; Cytotoxic T lymphocyte associated antigen 8; Cytotoxic T lymphocyte associated protein 8; Cytotoxic T lymphocyte associated serine esterase 8; Cytotoxic T-lymphocyte-associated antigen 8; IL 17A; IL-17; IL-17A; IL17; IL17; Il17a; Interleukin 17 (cytotoxic T lymphocyte associated serine esterase 8); Interleukin 17A; Interleukin-17A; Interleukin17; Interleukin17A; OTTHUMP00000016597; OTTMUSP00000046003]

[interleukin-17A; Interleukin-17A; interleukin-17A; interleukin 17A; Cytotoxic T-lymphocyte-associated antigen 8; CTLA-8]

[IL17A]

[Il17a; Il17a; Il17; Ctla8; IL-17; Ctla-8; IL-17A; Ctla8; Il17; IL-17; IL-17A; CTLA-8]

Polyclonal

IgG

Rabbit

Mouse, Rat

158

Affinity purification

PBS with 0.02% sodium azide, 100 ug/ml BSA and 50% glycerol.

Store at -20 degree C. Avoid freeze/thaw cycles.

Immunohistochemistry (IHC)

IHC: 1:300-1:1000

Immunohistochemistry (IHC)

Immunohistochemistry (IHC)

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse IL-17A

Note: Centrifuge before opening to ensure complete recovery of vial contents.

Cancer; Immunology

IL17A, also named as IL-17, is a proinflammatory cytokine. IL-17,synthesized only by memory T cells and natural killer cells, has pleiotropic effects,mainly in the recruitment and activation of neutrophils. This cytokine regulates the activities of NF-kappaB and mitogenactivated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2),as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis,psoriasis and multiple sclerosis. The IL-17 receptor is a type I transmembrane protein,that is widely expressed on epithelial cells,fibroblasts,B and T cells,and monocytic cells. In psoriatic skin lesions,both Th17 cells and their downstream effector molecules,e.g. IL-17 and IL-22,are highly increased.

6754324

NP_034682.1

NM_010552.3

Q62386

Cytokine-cytokine Receptor Interaction Pathway (83248); Cytokine-cytokine Receptor Interaction Pathway (460); Rheumatoid Arthritis Pathway (200310); Rheumatoid Arthritis Pathway (200269)

This gene encodes a pro-inflammatory cytokine that is a member of the interleukin-17 family. The encoded protein plays a central role in host defense against diverse pathogens. The encoded protein is produced by activated T-cells and certain cell types of innate immune system. The active protein functions as either a homodimer with other interleukin-17 family members and signals through the interleukin-17 receptor to induce inflammatory cytokine production. Aberrant expression of this gene is associated with autoinflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Sep 2015]

Ligand for IL17RA (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (). Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines ().

0.06 mL

150 USD

0.12 mL

225

0.2 mL

360