protein

Recombinant Human Small Ubiquitin-Related Modifier 2/SUMO2 Protein (N-6His)

MBS2553243

0.01 mg

70 USD

Recombinant Protein

Recombinant Human Small Ubiquitin-Related Modifier 2/SUMO2 Protein (N-6His)

[Small Ubiquitin-Related Modifier 2/SUMO2]

[Small Ubiquitin-Related Modifier 2; SUMO-2; HSMT3; SMT3 homolog 2; SUMO-3; Sentrin-2; Ubiquitin-Like Protein SMT3A; Smt3A; SUMO2; SMT3A; SMT3H2]

[small ubiquitin-related modifier 2 isoform b; Small ubiquitin-related modifier 2; small ubiquitin-related modifier 2; small ubiquitin-like modifier 2; HSMT3]

[SUMO2]

[SUMO2; SUMO2; HSMT3; SMT3B; SUMO3; Smt3A; SMT3H2; SMT3B1 PublicationManual assertion based on opinion iniRef.8; Smt3B1 PublicationManual assertion based on opinion iniRef.8]

E Coli

[Met1-Gly93]

71

>95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

The product is shipped at ambien temperature. Upon receipt, store it inmediately at the temperature listede below.

Testing Data (TD)

Species: Human

Endotoxin: <1.0 EU per ug as determined by LAL test. Fusion Tag: N-6His

Small Ubiquitin-Related Modifier 2 (SUMO2) is an Ubiquitin-like protein that belongs to the ubiquitin family with SUMO subfamily. It is a family of small, related proteins that can be enzymatically attached to a target protein by a post-translational modification process termed sumoylation. SUMO2 can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptidebond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.

54792071

NP_001005849.1

NP_001005849.1

P61956

Molecular Mass: 13.0 kDa. Actual Protein Molecular Mass: 17 kDa

Glucocorticoid Receptor Regulatory Network Pathway (138014); Nuclear Pore Complex Pathway (470351); RNA Transport Pathway (177876); RNA Transport Pathway (175229); Wnt Signaling Pathway NetPath (198799)

This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last two amino acids of the carboxy-terminus have been cleaved off. Numerous pseudogenes have been reported for this gene. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2, CBX4 or ZNF451 (PubMed:26524494). This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (PubMed:18408734, PubMed:18538659, PubMed:21965678, PubMed:9556629). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744).

0.01 mg

70 USD

0.05 mg

100