product summary
request information :
company name :
MyBioSource
product type :
protein
product name :
Perforin 1 (PRF1)
catalog :
MBS254973
quantity :
0.01 mg
price :
370 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS254973
products type :
Recombinant Protein
products full name :
Perforin 1 (PRF1)
products short name :
Perforin 1 (PRF1)
other names :
perforin-1; Perforin-1; perforin-1; cytolysin; lymphocyte pore forming protein; lymphocyte pore-forming protein; perforin 1 (pore forming protein); Cytolysin; Lymphocyte pore-forming protein; PFP
products gene name :
PRF1
other gene names :
PRF1; PRF1; P1; PFP; FLH2; PFN1; HPLH2; PFP; P1; PFP
uniprot entry name :
PERF_HUMAN
host :
E Coli
sequence length :
555
sequence :
The target protein is fused with two N"-terminal Tags, His-tag and GST-tag, its sequence is listed below. V WM AGE G M D V T TLRRSGSFPV NTQRFLRPDR TCTLCKNSLM RDATQRLPVA ITHWRPHSSH CQRNVAAAKV HSTEGVAREAAANINNDWRV GLDVNPRPEA NMRASVAGSH SKVANFAAEK TYQDQYNFNS DTVECRMYSF RLVQKPPLHL DFKKALRALP RNFNSSTEHA YHRLlSSYGT HFITAVDLGG RISVLTALRT CQLTLNGLTA DEVGDCLNVE AQVSIGAQAS VSSEYKACEE .KKKQHKMATS FHQTYRERHV EVLGGPLDST HDLLFGNQAT PEQFSTWTAS LPSNPGLVDY SLEPLHTLLE EQNPK
purity :
>95%
form :
Supplied as lyophilized form in PBS, pH 7.4, containing 1mM DTT, 0.1% sarcosyl, 5% trehalose and preservative.
storage stability :
Store at 2-8 degree C for 1 month. Aliquot and store at -80 degree C for 12 months.
tested application :
SDS-PAGE; Western Blot (WB); ELISA (EIA); Immunoprecipitation (IP)
other info1 :
Tag Information: two N-terminal Tags, His-tag and GST-tag. Residues: Val40-Lys355 (Accession #P10820), with two N-terminal Tags, His-tag and GST-tag. Subcellular Location: Cytoplasmic granule lumen. Secreted. Cell membrane; Multi-pass membrane protein. Endosome lumen.
other info2 :
Organism: Mus musculus (Mouse). Endotoxin Level: 6.8. Predicted Molecular Mass: 67.2 kDa. Reconstitution: Reconstitute in sterile PBS, pH 7.2-pH7.4
ncbi gi num :
133908621
ncbi acc num :
NP_001076585.1
ncbi gb acc num :
NM_001083116.1
ncbi mol weight :
61,377 Da
ncbi pathways :
Allograft Rejection Pathway 920963!!Allograft Rejection Pathway 83123!!Allograft Rejection Pathway 535!!Apoptosis Pathway 198797!!Autoimmune Thyroid Disease Pathway 83121!!Autoimmune Thyroid Disease Pathway 533!!Caspase Cascade In Apoptosis Pathway 137974!!Downstream Signaling In Naive CD8+ T Cells Pathway 138018!!Graft-versus-host Disease Pathway 83124!!Graft-versus-host Disease Pathway 536
ncbi summary :
The protein encoded by this gene has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
size :
0.01 mg
price :
370 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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