catalog number :
MBS2549155
products full name :
NSA2 Monoclonal Antibody
products short name :
[NSA2]
products name syn :
[CDK105, Hairy cell leukemia protein 1, HCLG1,HUSSY29, NSA2,TINP1, YR 29]
other names :
[ribosome biogenesis protein NSA2 homolog isoform 2; Ribosome biogenesis protein NSA2 homolog; ribosome biogenesis protein NSA2 homolog; NSA2, ribosome biogenesis homolog; Hairy cell leukemia protein 1; TGF-beta-inducible nuclear protein 1]
products gene name :
[NSA2]
products gene name syn :
[TINP1]
other gene names :
[NSA2; NSA2; HCLG1; TINP1; CDK105; HCL-G1; HUSSY29; HUSSY-29; TINP1]
purity :
Protein G purification
storage stability :
Store at -20°C. Avoid freeze / thaw cycles.
tested application :
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
app notes :
WB: 1:1000-1:10000. IHC: 1:50-1:500
image1 heading :
Western Blot (WB)
other info1 :
Immunogen: Fusion protein of TINP1. Calculated: 260aa,30kDa. Observed: 34kDa
other info2 :
Buffer: PBS with 0.02% sodium azide, 50% glycerol, PH7.3. Conjugation: Unconjugated
products categories :
Epigenetics and Nuclear Signaling
products description :
TINP1 (TGF beta inducible nuclear protein 1) was widely expressed in various cell lines. TINP1 overexpression significantly promoted tumor cell proliferation, which may be associated with the downregulation of p53 expression. Furthermore, TINP1 promoted a number of cell lines to the S phase of the cell cycle. TINP1 promotes cell proliferation and significantly reduces p53 and p21 expression.
ncbi acc num :
NP_001258594.1
ncbi gb acc num :
NM_001271665.1
ncbi summary :
This gene encodes a nucleolar protein involved in cell cycle regulation and proliferation. This gene was identified based on sequence similarity to a highly conserved Saccharomyces cerevisiae gene encoding a pre-ribosomal protein, which is involved in large ribosomal subunit biogenesis. The encoded protein is found at elevated levels in diabetic nephropathy. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified. [provided by RefSeq, Nov 2012]
uniprot summary :
Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles ().