SGK1 Monoclonal Antibody | MyBioSource MBS2548977 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

SGK1 Monoclonal Antibody

catalog :

MBS2548977

quantity :

0.02 mL

price :

110 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

[4D12]

reactivity :

human, mouse, rat

application :

immunohistochemistry, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

image

image 1 :

Immunohistochemistry of paraffinembedded Human brain tissue using SGK1 Monoclonal Antibody at dilution of 1:200.

image 2 :

Immunohistochemistry of paraffinembedded Human kidney carcinoma tissue using SGK1 Monoclonal Antibody at dilution of 1:200.

product information

catalog number :

MBS2548977

products type :

Antibody

products full name :

SGK1 Monoclonal Antibody

products short name :

[SGK1]

products name syn :

[SGK1]

other names :

[serine/threonine-protein kinase Sgk1 isoform 2; Serine/threonine-protein kinase Sgk1; serine/threonine-protein kinase Sgk1; serum/glucocorticoid regulated kinase 1; Serum/glucocorticoid-regulated kinase 1]

products gene name :

[SGK1]

other gene names :

[SGK1; SGK1; SGK; SGK]

clonality :

Monoclonal

isotype :

IgG

clone :

[4D12]

host :

Mouse

reactivity :

Human, Mouse, Rat

purity :

Protein A purification

storage stability :

Store at -20 degree C. Avoid freeze / thaw cycles.

tested application :

Immunohistochemistry Paraffin (IHC-p)

app notes :

IHC: 1:100-200

image1 heading :

Immunohistochemistry (IHC)

image2 heading :

Immunohistochemistry

other info1 :

Immunogen: Synthetic Peptide of SGK1

other info2 :

Buffer: PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4. Note: Centrifuge before opening to ensure complete recovery of vial contents.

products description :

Protein kinase that plays an important role in cellular stress response. Activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability and renal sodium excretion. Sustained high levels and activity may contribute to conditions such as hypertension and diabetic nephropathy. Mediates cell survival signals, phosphorylates and negatively regulates pro-apoptotic FOXO3A. Phosphorylates NEDD4L, which leads to its inactivation and to the subsequent activation of various channels and transporters such as ENaC, KCNA3/Kv1.3 or EAAT1. Isoform 2 exhibited a greater effect on cell plasma membrane expression of ENaC and Na(+) transport than isoform 1.

ncbi gi num :

219521876

ncbi acc num :

NP_001137148.1

ncbi gb acc num :

NM_001143676.1

uniprot acc num :

O00141

ncbi pathways :

Aldosterone-regulated Sodium Reabsorption Pathway (130626); Aldosterone-regulated Sodium Reabsorption Pathway (130590); Class I PI3K Signaling Events Pathway (138022); FSH Signaling Pathway (672455); FoxO Family Signaling Pathway (138036); Glucocorticoid Receptor Regulatory Network Pathway (138014); IL-6 Signaling Pathway (198864); Insulin Pathway (138026); Insulin Signaling Pathway (198845); Ion Channel Transport Pathway (187193)

ncbi summary :

This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]

uniprot summary :

SGK1: serum and glucocorticoid-inducible kinase is an AGC protein kinase of the SGK family. Rapidly induced in response to a variety of stimuli including serum, glucocorticoids, follicle stimulating hormone, osmotic shock and mineralocorticoids. Can be activated via PI3K-dependent and -independent pathways. Plays a role in activating certain potassium, sodium and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability and renal sodium excretion. SGK is negatively regulated by ubiquitin modification and proteasome degradation. Protein type: AGC group; EC 2.7.11.1; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); SGK family. Chromosomal Location of Human Ortholog: 6q23.2. Cellular Component: cytoplasm; cytosol; endoplasmic reticulum membrane; mitochondrion; nuclear speck; nucleus; plasma membrane. Molecular Function: ATP binding; calcium channel regulator activity; chloride channel regulator activity; potassium channel regulator activity; protein binding; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; sodium channel regulator activity. Biological Process: apoptosis; cellular response to DNA damage stimulus; long-term memory; neuron projection morphogenesis; peptidyl-serine phosphorylation; positive regulation of transporter activity; protein amino acid phosphorylation; regulation of apoptosis; regulation of blood pressure; regulation of catalytic activity; regulation of cell growth; regulation of cell migration; regulation of cell proliferation; regulation of transcription factor activity; renal sodium ion absorption; response to stress; sodium ion transport

size1 :

0.02 mL

price1 :

110 USD

size2 :

0.06 mL

price2 :

150

size3 :

0.12 mL

price3 :

225

size4 :

0.2 mL

price4 :

360

more info or order :

MyBioSource product webpage