product summary
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company name :
MyBioSource
product type :
other
product name :
Choline Acetyltransferase (CHAT) Assay Kit (Tissue samples)
catalog :
MBS2548424
quantity :
40 Assays
price :
290 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS2548424
products type :
Assay Kit
products full name :
Choline Acetyltransferase (CHAT) Assay Kit (Tissue samples)
products short name :
[Choline Acetyltransferase (CHAT)]
other names :
[choline acetyltransferase; Choline O-acetyltransferase; choline O-acetyltransferase; choline O-acetyltransferase]
products gene name :
[CHAT]
other gene names :
[CHAT; CHAT; CMS6; CMS1A; CMS1A2; CHOACTASE; CHOACTase; ChAT; Choline acetylase]
sequence length :
748
storage stability :
The kit is stable for 6 months at 2-8 degree C before opening.
products description :
Principle of the Assay: Acetyl-CoA can react with choline under the catalysis of choline acetyltransferase (ChAT) and the reaction products can combine with the chromogenic reagent. The activity of ChAT is calculated by measuring the OD value at 324 nm.
ncbi gi num :
301096
ncbi acc num :
AAA14245.1
ncbi mol weight :
70,394 Da
ncbi pathways :
Acetylcholine Neurotransmitter Release Cycle Pathway (1268773); Acetylcholine Synthesis Pathway (198820); Biogenic Amine Synthesis Pathway (198793); Cholinergic Synapse Pathway (217716); Glycerophospholipid Biosynthesis Pathway (1270054); Glycerophospholipid Metabolism Pathway (82989); Glycerophospholipid Metabolism Pathway (364); Metabolism Pathway (1269956); Metabolism Of Lipids And Lipoproteins Pathway (1270001); Neuronal System Pathway (1268763)
ncbi summary :
This gene encodes an enzyme which catalyzes the biosynthesis of the neurotransmitter acetylcholine. This gene product is a characteristic feature of cholinergic neurons, and changes in these neurons may explain some of the symptoms of Alzheimer's disease. Polymorphisms in this gene have been associated with Alzheimer's disease and mild cognitive impairment. Mutations in this gene are associated with congenital myasthenic syndrome associated with episodic apnea. Multiple transcript variants encoding different isoforms have been found for this gene, and some of these variants have been shown to encode more than one isoform. [provided by RefSeq, May 2010]
uniprot summary :
CHAT: an enzyme that catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses. Four alternative splice variants have been described. Protein type: Acetyltransferase; EC 2.3.1.6; Lipid Metabolism - glycerophospholipid. Chromosomal Location of Human Ortholog: 10q11.23. Cellular Component: cytoplasm; cytosol; nucleus. Molecular Function: choline O-acetyltransferase activity. Biological Process: neurotransmitter secretion; phosphatidylcholine biosynthetic process. Disease: Myasthenic Syndrome, Congenital, Associated With Episodic Apnea
size1 :
40 Assays
price1 :
290 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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