Recombinant Mouse Transferrin / CD176 / Serotransferrin Protein (Fc tag) | MyBioSource MBS2546773 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Mouse Transferrin / CD176 / Serotransferrin Protein (Fc tag)

catalog :

MBS2546773

quantity :

0.05 mg

price :

405 USD

more info or order :

MyBioSource product webpage

image

image 1 :

product information

catalog number :

MBS2546773

products type :

Recombinant Protein

products full name :

Recombinant Mouse Transferrin / CD176 / Serotransferrin Protein (Fc tag)

products short name :

[Transferrin / CD176 / Serotransferrin]

products name syn :

[TRF, Tf]

other names :

[serotransferrin; Serotransferrin; serotransferrin; transferrin; Beta-1 metal-binding globulin; Siderophilin]

products gene name :

[CD176]

other gene names :

[Trf; Tf; HP; Tf; Tfn; hpx; Cd176; AI266983; Trf; Transferrin]

host :

Human Cells

sequence length :

697

purity :

> 90 % as determined by SDS-PAGE

form :

Lyophilized from sterile PBS, pH7.4, 5% Trehalose, 5% mannitol, 0.01% Tween-80

storage stability :

Store it under sterile conditions at -20 degree C to -80 degree C upon receiving. Recommend to aliquot the protein into smaller quantities for optimal storage.

app notes :

The recombinant mouse TRF/Fc is a disulfide-linked homodimer. The reduced monomer comprises 919 amino acids and has a predicted molecular mass of 101.9 kDa. The apparent molecular mass of the protein is approximately 102 kDa in SDS-PAGE under reducing conditions due to glycosylation.

image1 heading :

SDS-PAGE

other info1 :

Predicted N Terminal: Val 20

other info2 :

Endotoxin: < 1.0 EU per ug of the protein as determined by the LAL method. Reconstitution: It is recommended that sterile water (400 ?l) be added to the vial to prepare a stock solution of 0.25 mg/mL. Concentration is measured by UV-Vis.

products description :

Background: Transferrin is a glycoprotein with an approximate molecular weight of 76.5 kDa. This glycoprotein is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of Transferrin is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte / pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum. Transferrins are iron binding transport proteins which bind Fe3+ ion in association with the binding of an anion, usually bicarbonate. This transferrin binds only one Fe3+ ion per protein molecule. Transports iron ions from the hemolymph into the eggs during the vitellogenic stage. Transferrins are iron binding transport proteins which can bind two Fe (3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation. When a transferrin loaded with iron encounters with a transferring receptor on cell surface, transferring binds to it and, as a consequence, is transported into the cell in a visicle by receptor-mediated endocytosis. The PH is reduced by hydrogen iron pumps. The lower pH causes transferrin to release its iron ions. The receptor is then transported through the endocytic cycle back to the cell surface, ready for another round of iron uptake. Each transferrin molecule has the ability to carry two iron ions in the ferric form. Description: A DNA sequence encoding the mouse TRF (Q921I1) (Met1-His697) was expressed with the Fc region of human IgG1 at the C-terminus.

ncbi gi num :

20330802

ncbi acc num :

NP_598738.1

ncbi gb acc num :

NM_133977.2

uniprot acc num :

Q921I1

ncbi mol weight :

76,724 Da

ncbi pathways :

Cargo Recognition For Clathrin-mediated Endocytosis Pathway (1427402); Clathrin-mediated Endocytosis Pathway (1427401); HIF-1 Signaling Pathway (695223); Hemostasis Pathway (1368135); Iron Homeostasis Pathway (198312); Iron Uptake And Transport Pathway (1368042); Membrane Trafficking Pathway (1367174); Mineral Absorption Pathway (212238); Mineral Absorption Pathway (212220); Platelet Activation, Signaling And Aggregation Pathway (1368145)

uniprot summary :

TF: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation. Defects in TF are the cause of atransferrinemia (ATRAF). Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia. Belongs to the transferrin family. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 9 F1 9 55.03 cM. Cellular Component: apical plasma membrane; basal plasma membrane; basement membrane; cell surface; coated pit; cytoplasmic vesicle; early endosome; endocytic vesicle; endosome; extracellular region; extracellular space; extrinsic to external side of plasma membrane; late endosome; membrane; perinuclear region of cytoplasm; recycling endosome; vesicle. Molecular Function: ferric iron binding; ferrous iron binding; protein binding. Biological Process: actin filament organization; activation of JNK activity; ferric iron transport; iron ion transport; osteoclast differentiation; positive regulation of bone resorption; positive regulation of myelination; positive regulation of phosphorylation; positive regulation of receptor-mediated endocytosis; positive regulation of transcription, DNA-dependent

size1 :

0.05 mg

price1 :

405 USD

size2 :

0.1 mg

price2 :

635

more info or order :

MyBioSource product webpage