Recombinant Human Coagulation Factor XIII B chain / F13B Protein (His tag) | MyBioSource MBS2545766 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Coagulation Factor XIII B chain / F13B Protein (His tag)

catalog :

MBS2545766

quantity :

0.02 mg

price :

365 USD

more info or order :

MyBioSource product webpage

image

image 1 :

product information

catalog number :

MBS2545766

products type :

Recombinant Protein

products full name :

Recombinant Human Coagulation Factor XIII B chain / F13B Protein (His tag)

products short name :

[Coagulation Factor XIII B chain / F13B]

products name syn :

[Coagulation factor 13; Coagulation factor XIII; FXIIIB]

other names :

[coagulation factor XIII B chain; Coagulation factor XIII B chain; coagulation factor XIII B chain; coagulation factor XIII B chain; Fibrin-stabilizing factor B subunit; Protein-glutamine gamma-glutamyltransferase B chain; Transglutaminase B chain]

products gene name :

[F13B]

other gene names :

[F13B; F13B; FXIIIB]

host :

HEK293 Cells

purity :

> 95 % as determined by reducing SDS-PAGE.

form :

Lyophilized from sterile PBS, pH 7.4,5% Trehalose, 5% mannitol, 0.01% Tween-80.

storage stability :

Shipping: Blue Ice. Lyophilized proteins are stable for up to 12 months when stored at -20°C to-80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

image1 heading :

SDS-PAGE

other info1 :

Species: Human. Sequence: Met 1-Thr 661. Tag: C-His. Endotoxin: < 1.0 EU per ug as determined by the LAL method. Reconsitution: It is recommended that sterile water (80 ul) be added to the vial to prepare a stock solution of 0.25mg/mL. Concentration is measured by UV-Vis.

products description :

Coagulation factor XIII B chain, also known as Fibrin-stabilizing factor B subunit, Protein-glutamine gamma-glutamyltransferase B chain, Transglutaminase B chain and F13B, is a secreted protein which contains 10 Sushi (CCP / SCR) domains. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as a plasma carrier molecules. Platelet factor XIII is composed of just 2 A subunits, which are identical to those of plasma origin. The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin. Factor XIII acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. Defects in F13B are the cause of factor XIII subunit B deficiency (FA13BD) which is an autosomal recessive disorder characterized by a life-long bleeding tendency, impaired wound healing and spontaneous abortion in affected women.

ncbi gi num :

110611237

ncbi acc num :

NP_001985.2

ncbi gb acc num :

NM_001994.2

uniprot acc num :

P05160

ncbi mol weight :

Mol_Mass: 74.5 kDa. AP_Mol_Mass: 65 kDa

ncbi pathways :

Blood Clotting Cascade Pathway (198840); Common Pathway (106060); Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Formation Of Fibrin Clot (Clotting Cascade) Pathway (106057); Hemostasis Pathway (106028); Prostate Cancer Pathway (755440); Steroid Biosynthesis Pathway (198866)

ncbi summary :

This gene encodes coagulation factor XIII B subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as a plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon activation by the cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq, Jul 2008]

uniprot summary :

F13B: The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin. Defects in F13B are the cause of factor XIII subunit B deficiency (FA13BD). FA13BD is an autosomal recessive disorder characterized by a life-long bleeding tendency, impaired wound healing and spontaneous abortion in affected women. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 1q31.3. Cellular Component: extracellular region. Biological Process: blood coagulation. Disease: Factor Xiii, B Subunit, Deficiency Of

size1 :

0.02 mg

price1 :

365 USD

size2 :

0.05 mg

price2 :

735

more info or order :

MyBioSource product webpage