Recombinant Human Cystatin SN / CST1 Protein (His tag) | MyBioSource MBS2545742 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Cystatin SN / CST1 Protein (His tag)

catalog :

MBS2545742

quantity :

0.01 mg

price :

405 USD

more info or order :

MyBioSource product webpage

image

image 1 :

product information

catalog number :

MBS2545742

products type :

Recombinant Protein

products full name :

Recombinant Human Cystatin SN / CST1 Protein (His tag)

products short name :

[Cystatin SN / CST1]

products name syn :

[CST1]

other names :

[cystatin-SN; Cystatin-SN; cystatin-SN; cystatin SN; Cystain-SA-I; Cystatin-1; Salivary cystatin-SA-1]

products gene name :

[CST1]

other gene names :

[CST1; CST1]

host :

Human Cells

sequence length :

141

purity :

> 97 % as determined by SDS-PAGE

form :

Lyophilized from sterile PBS, pH 7.4, 5% Trehalose, 5% mannitol, 0.01% Tween 80

storage stability :

Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted and be used as soon as possible. Avoid repeated freeze-thaw cycles.

app notes :

The secreted recombinant human CST1 consists of 132 amino acids and has a calculated molecular mass of 15.6 kDa. It migrates as an approximately 17 kDa band in SDS-PAGE under reducing conditions as predicted.

image1 heading :

SDS-PAGE

other info1 :

Predicted N Terminal: Trp 21. Source: Human

other info2 :

Endotoxin: < 1.0 EU per ug of the protein as determined by the LAL method. Reconstitution: It is recommended that sterile water (130 uL) be added to the vial to prepare a stock solution of 0.15 mg/mL. Concentration is measured by UV-Vis. Stability: Samples are stable for up to twelve months from date of receipt at -70°C

products description :

Background: Cystatin-SN, also known as Cystain-SA-I, Cystatin-1, Salivary cystatin-SA-1 and CST1, is a secreted protein which belongs to the cystatin family. The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. Cystatin-SN / CST1 is expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level). Cystatin-SN / CST1 is also expressed in saliva, tears, urine and seminal fluid. Human saliva appears to contain several cysteine proteinase inhibitors that are immunologically related to cystatin S but that differ in their specificity due to amino acid sequence differences. Human salivary cystatins include Cystatin-S, Cystatin-S1, Cystatin-S2, Cystatin- SA, Cystatin-SN, Cystatin-C and Cystatin-D. Cystatin-SN is a much better inhibitor of papain and dipeptidyl peptidase I than is cystatin-S, although both inhibit ficin equally well. Description: A DNA sequence encoding the human CST1 (P01037-1) (Met 1-Ser 141) was fused with a polyhistidine tag at the C-terminus.

ncbi gi num :

19882251

ncbi acc num :

NP_001889.2

ncbi gb acc num :

NM_001898.2

uniprot acc num :

P01037

ncbi mol weight :

ncbi pathways :

Salivary Secretion Pathway (153376); Salivary Secretion Pathway (153352)

ncbi summary :

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a cysteine proteinase inhibitor found in saliva, tears, urine, and seminal fluid. [provided by RefSeq, Jul 2008]

uniprot summary :

CST1: Human saliva appears to contain several cysteine proteinase inhibitors that are immunologically related to cystatin S but that differ in their specificity due to amino acid sequence differences. Cystatin SN, with a pI of 7.5, is a much better inhibitor of papain and dipeptidyl peptidase I than is cystatin S, although both inhibit ficin equally well. Belongs to the cystatin family. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 20p11.21. Cellular Component: extracellular space. Molecular Function: protease binding; protein binding. Biological Process: detection of chemical stimulus involved in sensory perception of bitter taste

size1 :

0.01 mg

price1 :

405 USD

size2 :

0.02 mg

price2 :

635

more info or order :

MyBioSource product webpage