protein

Recombinant Human STC2 / Stanniocalcin 2 Protein (Fc tag)

MBS2545268

0.02 mg

330 USD

Recombinant Protein

Recombinant Human STC2 / Stanniocalcin 2 Protein (Fc tag)

[STC2 / Stanniocalcin 2]

[STC2]

[stanniocalcin-2; Stanniocalcin-2; stanniocalcin-2; stanniocalcin 2; Stanniocalcin-related protein; STC-related protein; STCRP]

[STC2]

[STC2; STC2; STC-2; STCRP; STC-2; STC-related protein; STCRP]

302

> 85 % as determined by SDS-PAGE

Lyophilized from sterile PBS, pH 7.4, 5% trehalose, 5% mannitol, 0.01% Tween80

Storage: Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted and be used as soon as possible. Avoid repeated freeze-thaw cycles. Stability : Samples are stable for up to twelve months from date of receipt at -70°C

SDS-PAGE

Predicted N Terminal: Thr 25. Source: Human. Expression Host: Human cells. Protein Construction: A DNA sequence encoding the human STC2 (O76061) (Met1-Arg302) was expressed with the Fc region of human IgG1 at the C-terminus. Molecular Mass: The recombinant human STC2/Fc is a disulfide-linked homodimer. The reduced monomer comprises 519 amino acids and has a predicted molecular mass of 57.7 kDa. The apparent molecular mass of the protein is approximately 63 kDa in SDS-PAGE under reducing conditions.

Endotoxin: < 1.0 EU per mug of the protein as determined by the LAL method. Reconstitution: It is recommened that sterile water (200ul) be added to the vial to prepare a stock solution of 0.25 mg/ml. Concentration is measured by UV-Vis

STC2 is a secreted, homodimeric glycoprotein which expressed in a wide variety of tissues. STC2 has an anti-hypocalcemic action on calcium and phosphate homeostasis. It may have autocrine or paracrine functions. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. STC2 has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. It may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis.

4507267

NP_003705.1

NM_003714.2

O76061

This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Constitutive overexpression of human stanniocalcin 2 in mice resulted in pre- and postnatal growth restriction, reduced bone and skeletal muscle growth, and organomegaly. Expression of this gene is induced by estrogen and altered in some breast cancers. [provided by RefSeq, Jul 2008]

STC2: a secreted protein that has an anti-hypocalcemic action on calcium and phosphate homeostasis. Expressed in a variety of tissues including muscle, heart, pancreas, kidney, spleen, prostate, small intestine, colon and peripheral blood leucocytes. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 5q35.2. Cellular Component: endoplasmic reticulum; extracellular space; perinuclear region of cytoplasm. Molecular Function: enzyme binding; heme binding; protein homodimerization activity. Biological Process: regulation of hormone biosynthetic process

0.02 mg

330 USD

0.1 mg

735