antibody

Rabbit anti Mouse IFNAR1  Monoclonal Antibody

MBS2544586

0.06 mL

215 USD

monoclonal

rabbit

nonconjugated

human, mouse

ELISA, enzyme immunoassay

Antibody

Rabbit anti Mouse IFNAR1  Monoclonal Antibody

[IFNAR1 ]

[interferon alpha/beta receptor 1; Interferon alpha/beta receptor 1; interferon alpha/beta receptor 1; interferon alpha and beta receptor subunit 1; Cytokine receptor class-II member 1; Cytokine receptor family 2 member 1; CRF2-1; Type I interferon receptor 1]

[IFNAR1 ]

[IFNAR1; IFNAR1; AVP; IFRC; IFNAR; IFNBR; IFN-alpha-REC; IFNAR; IFN-R-1; IFN-alpha/beta receptor 1; CRF2-1]

INAR1_HUMAN

Monoclonal

IgG

Rabbit

Mouse

557

Store at -20°C, Avoid freeze/thaw cycles

ELISA (EIA)

ELISA: 1/5000-1/1000

Immunogen: Recombinant Mouse IFNAR-1 protein. Buffer: PBS with 0.05% sodium azide, 30% glycerol and 5% trehasole. Produce: This antibody was obtained from rabbit immunized with purified, recombinant Mouse IFNAR1

Interferon-alpha/beta receptor alpha chain (IFNAR1) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. Tyk2 slows down IFNAR1 degradation and that this is due, at least in part, to inhibition of IFNAR1 endocytosis. Mutant versions of IFNAR1, in which Tyr466 is changed to phenylalanine, can act in a dominant negative manner to inhibit phosphorylation of STAT2. These observations are consistent with a model in which IFNAR1 mediates the interaction between JAK kinases and the STAT transcription factors.

46488932

NM_000629.2

Cytokine Signaling In Immune System Pathway (1269310); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Downstream Signaling In Naive CD8+ T Cells Pathway (138018); Hepatitis B Pathway (694606); Hepatitis C Pathway (173973); Hepatitis C Pathway (173907); Herpes Simplex Infection Pathway (377873); Herpes Simplex Infection Pathway (377865); Immune System Pathway (1269170)

The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. [provided by RefSeq, Jul 2008]

IFNAR1: receptor for interferons alpha and beta. Belongs to the type II cytokine family of receptors. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves. Tyk2 tyrosine kinase is essential for stable cell surface expression of IFNAR1. Present in all tissues and even on the surface of most IFN-resistant cells. Protein type: Membrane protein, integral; Receptor, cytokine. Chromosomal Location of Human Ortholog: 21q22.11. Cellular Component: integral to plasma membrane; plasma membrane. Molecular Function: interferon-alpha/beta binding; interferon-alpha/beta receptor activity; protein binding. Biological Process: JAK-STAT cascade; response to lipopolysaccharide; response to virus

0.06 mL

215 USD

0.12 mL

330

0.2 mL

500