Rabbit anti Human B2M Monoclonal Antibody | MyBioSource MBS2544321 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit anti Human B2M Monoclonal Antibody

catalog :

MBS2544321

quantity :

0.06 mL

price :

215 USD

clonality :

monoclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunoprecipitation

more info or order :

MyBioSource product webpage

image

image 1 :

Western Blot analysis of Hela cells using B2M Monoclonal Antibody at dilution of 1:20.

product information

catalog number :

MBS2544321

products type :

Antibody

products full name :

Rabbit anti Human B2M Monoclonal Antibody

products short name :

[B2M ]

products name syn :

[B2M ,CDABP0092,Hdcma22p,IMD43]

other names :

[B2M, partial; Beta-2-microglobulin; beta-2-microglobulin; beta-2-microglobulin]

products gene name :

[B2M ]

other gene names :

[B2M; B2M; IMD43]

uniprot entry name :

B2MG_HUMAN

clonality :

Monoclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human

sequence length :

119

purity :

Affinity purification

storage stability :

Store at -20°C.Avoid freeze / thaw cycles .

tested application :

Western Blot (WB), Immunoprecipitation (IP)

app notes :

Western Blot (WB) 1:20-1:50

image1 heading :

Western Blot (WB)

other info1 :

Immunogen: Recombinant Human B2M microglobulin protein . Buffer: 0.2 um filtered solution in PBS with 5% trehalose

products description :

B2M, also known as beta2-Microglobulin or CDABP0092, is a component of MHC class I molecules found expression in all nucleated cells (excludes red blood cells). The major function of MHC class I moleculesis is to display fragments of proteins from within the cell to T-cells and cells containing foreign proteins will be attacked. B2M (beta2-Microglobulin) is a low molecular weight protein. It was demonstrated that B2M (beta2-Microglobulin) was localized in the membranes of nucleated cells and was found to be associated with HL-A antigens.B2M (beta2- Microglobulin) is present in free form in various body fluids and as a subunit of histocompatibility antigens on cell surfaces lateral to thealpha3 chain. Unlikealpha3, beta2 has no transmembrane region. Directly above beta2 lies the alpha1 chain, which itself is lateral to the alpha2. In the absence of B2M (beta2 microglobulin), very limited amounts of MHC class I (classical and non-classical) molecules can be detected on the surface. In the absence of MHC class I, CD8 T cells, a subset of T cells involved in the development of acquired immunity cannot develop. Low levels of B2M (beta2 microglobulin) can indicate non-progression of HIV.

ncbi gi num :

823672134

ncbi pathways :

Adaptive Immune System Pathway (1269171); Amyloid Fiber Formation Pathway (1269169); Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway (1269194); Antigen Processing And Presentation Pathway (83074); Antigen Processing And Presentation Pathway (485); Antigen Processing-Cross Presentation Pathway (1269195); Class I MHC Mediated Antigen Processing Presentation Pathway (1269192); Cytokine Signaling In Immune System Pathway (1269310); DAP12 Interactions Pathway (1269283); DAP12 Signaling Pathway (1269284)

ncbi summary :

This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Aug 2014]

uniprot summary :

B2M: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Heterodimer of an alpha chain and a beta chain. Beta-2- microglobulin is the beta-chain of major histocompatibility complex class I molecules. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis. Belongs to the beta-2-microglobulin family. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 15q21.1. Cellular Component: cytoplasm; early endosome membrane; endoplasmic reticulum lumen; extracellular region; extracellular space; focal adhesion; Golgi apparatus; Golgi membrane; membrane; phagocytic vesicle membrane; plasma membrane. Molecular Function: glycoprotein binding; identical protein binding; protein binding. Biological Process: antibacterial humoral response; antigen processing and presentation of endogenous peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; antigen processing and presentation of peptide antigen via MHC class I; cellular protein metabolic process; defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; innate immune response; iron ion homeostasis; positive regulation of protein binding; positive regulation of receptor-mediated endocytosis; positive regulation of T cell cytokine production; regulation of defense response to virus by virus; regulation of immune response; retinal homeostasis. Disease: Amyloidosis, Familial Visceral; Hypoproteinemia, Hypercatabolic

size1 :

0.06 mL

price1 :

215 USD

size2 :

0.12 mL

price2 :

330

size3 :

0.2 mL

price3 :

500

more info or order :

MyBioSource product webpage