antibody

Rabbit anti Human SLAMF6  Monoclonal Antibody

MBS2544315

0.06 mL

215 USD

monoclonal

rabbit

nonconjugated

immunohistochemistry, immunohistochemistry - paraffin section

Antibody

Rabbit anti Human SLAMF6  Monoclonal Antibody

[SLAMF6 ]

[SLAM family member 6 isoform 4; SLAM family member 6; SLAM family member 6; SLAM family member 6; Activating NK receptor; NK-T-B-antigen; NTB-A; CD_antigen: CD352]

[SLAMF6 ]

[SLAMF6; SLAMF6; KALI; NTBA; CD352; KALIb; Ly108; NTB-A; SF2000; KALI; NTB-A]

SLAF6_HUMAN

Monoclonal

IgG

Rabbit

Human

221

Store at -20°C, Avoid freeze/thaw cycles

Immunohistochemistry (IHC) Paraffin

IHC-P: 1/100-1/1000

Immunohistochemistry (IHC)

Immunogen: Recombinant Human Ly108/SLAMF6 protein. Buffer: PBS with 0.05% sodium azide, 30% glycerol and 5% trehasole. Produce: This antibody was obtained from a rabbit immunized with purified recombinant Human Ly208/SLAMF6

Calculated MW: 37kDa

SLAM family member 6, also known as Activating NK receptor, NK-T-B-antigen, NTB-A, SLAMF6, KALI and Ly108, is a single-pass type I membrane protein which belongs to the CD2 subfamily of the immunoglobulin superfamily. SLAMF6/Ly108 contains one Ig-like (immunoglobulin-like) domain. It is expressed by all (resting and activated) natural killer cells (NK), T- and B-lymphocytes. SLAMF6/Ly108 triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. SLAMF6/Ly108 is a homodimer. It interacts with PTN6 and, upon phosphorylation, with PTN11 and SH2D1A/SAP. SLAMF6/Ly108 undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It may function as a coreceptor in the process of NK cell activation. SLAMF6/Ly108 can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients.

296040495

NM_001184716.1

Adaptive Immune System Pathway (1269171); Immune System Pathway (1269170); Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway (1269201)

The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It functions as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010]

SLAMF6: Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 1q23.2. Cellular Component: plasma membrane. Molecular Function: protein binding. Biological Process: positive regulation of interferon-gamma production; positive regulation of interleukin-17 production; positive regulation of natural killer cell mediated cytotoxicity; regulation of immune response

0.06 mL

215 USD

0.12 mL

330

0.2 mL

500