catalog number :
MBS2544146
products full name :
Rabbit anti Human IL22BP/IL22RA2 Monoclonal Antibody
products short name :
[IL22BP/IL22RA2 ]
products name syn :
[CRF2-10, IL-22RA2- CRF2-S1, ZcytoR16]
other names :
[interleukin-22 receptor subunit alpha-2; Interleukin-22 receptor subunit alpha-2; interleukin-22 receptor subunit alpha-2; interleukin 22 receptor subunit alpha 2; Cytokine receptor family type 2, soluble 1; CRF2-S1; Interleukin-22-binding protein; IL-22BP; IL22BP]
products gene name :
[IL22BP/IL22RA2 ]
other gene names :
[Il22ra2; Il22ra2; Crf2-s1; IL-22 receptor subunit alpha-2; IL-22R-alpha-2; IL-22RA2; CRF2-S1; IL-22BP; IL22BP]
uniprot entry name :
I22R2_RAT
purity :
Affinity purification
form :
PBS with 0.05% sodium azide, 50% glycerol.
storage stability :
Store at -20°C. Avoid freeze/thaw cycles.
tested application :
ELISA (EIA)
app notes :
ELISA 1:5000-1:10000
other info1 :
Immunogen: Recombinant Human IL22BP protein
other info2 :
Note: Centrifuge before opening to ensure complete recovery of vial contents.
products description :
Interleukin-22 receptor subunit alpha-2 (IL-22RA2), also known as interleukin-22-binding protein (IL-22BP), is a subunit of the receptor for interleukin 22. IL-22BP belongs to the type I I cytokine receptor family and contains 3 fibronectin type-III domains. IL-22BP/IL-22RA2 is expressed in a range of tissues, including those in the digestive, female reproductive, and immune systems. It is expressed in placenta, spleen, breast, skin and lung. It is also detected in intestinal tract, testis, brain, heart and thymus. The dominant cell types expressing IL-22BP/IL-22RA2 were mononuclear cells and epithelium. IL-22BP/IL-22RA2 may play an important role as an IL-22 antagonist in the regulation of inflammatory responses. Interleukin-22 (IL-22) is a member of IL-10 family. It is produced by T cells and induces the production of acute-phase reactants. IL-22 plays important roles in immune response through activation of the STAT 3 signal transduction pathway. Two types of IL-22-binding receptor have been discovered, a membrane-bound receptor and a soluble receptor.
ncbi gb acc num :
NM_001003404.1
ncbi pathways :
Cytokine Signaling In Immune System Pathway (1377233); Cytokine-cytokine Receptor Interaction Pathway (83443); Cytokine-cytokine Receptor Interaction Pathway (460); Immune System Pathway (1377119); Interleukin-19, 20, 22, 24 Pathway (1377253); Jak-STAT Signaling Pathway (83469); Jak-STAT Signaling Pathway (488); Signaling By Interleukins Pathway (1377241)
uniprot summary :
Receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses.