antibody

Rabbit anti Human TIMP1  Monoclonal Antibody

MBS2544120

0.06 mL

215 USD

monoclonal

rabbit

nonconjugated

ELISA, enzyme immunoassay

Antibody

Rabbit anti Human TIMP1  Monoclonal Antibody

[TIMP1 ]

[TIMP1; TIMP metallopeptidase inhibitor 1, isoform CRA_a; metalloproteinase inhibitor 1; TIMP metallopeptidase inhibitor 1; TIMP metallopeptidase inhibitor 1, isoform CRA_a]

[TIMP1 ]

[TIMP1; TIMP1; EPA; EPO; HCI; CLGI; TIMP; TIMP-1]

Q6FGX5_HUMAN

Monoclonal

IgG

Rabbit

Human

207

Affinity purification

Store at -20 degree C. Avoid freeze / thaw cycles

ELISA (EIA)

ELISA 1:5000-1:10000

Immunogen: Recombinant Human TIMP1 protein. Buffer: PBS with 0.05% sodium azide, 30% glycerol and 5% trehalose

Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors.

49456917

Q6FGX5

Calculated MW: 23kDa. Observed MW: Refer to Figures

Activation Of Matrix Metalloproteinases Pathway (1270258); Cytokine Signaling In Immune System Pathway (1269310); Degradation Of The Extracellular Matrix Pathway (1270257); Extracellular Matrix Organization Pathway (1270244); HIF-1 Signaling Pathway (695200); Hemostasis Pathway (1269340); IL-6 Signaling Pathway (198864); IL1 And Megakaryocytes In Obesity Pathway (1458186); IL6-mediated Signaling Events Pathway (137932); Immune System Pathway (1269170)

This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq, Jul 2008]

0.06 mL

215 USD

0.12 mL

330

0.2 mL

500