antibody

Rabbit anti Human Decorin  Monoclonal Antibody

MBS2543875

0.06 mL

215 USD

monoclonal

rabbit

nonconjugated

ELISA, enzyme immunoassay

Antibody

Rabbit anti Human Decorin  Monoclonal Antibody

[Decorin ]

[SLRR1B]

[decorin isoform a preproprotein; Decorin; decorin; decorin; Bone proteoglycan II; PG-S2; PG40]

[DCN; DCN; CSCD; PG40; PGII; PGS2; DSPG2; SLRR1B; SLRR1B]

PGS2_HUMAN

Monoclonal

IgG

Rabbit

Human

359

0.2 um filtered solution in PBS with 5% trehalose.

Store at -20°C. After freeze/thaw cycles.

ELISA (EIA)

ELISA 1:5000- 1:10000

Immunogen: Recombinant Human Decorin protein

This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients.

19743846

NM_133503.3

P07585

A Tetrasaccharide Linker Sequence Is Required For GAG Synthesis Pathway (1269981); BMP2-WNT4-FOXO1 Pathway In Human Primary Endometrial Stromal Cell Differentiation (1458222); CS/DS Degradation Pathway (1269987); Chondroitin Sulfate Biosynthesis Pathway (1269985); Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway (1269984); Defective B3GALT6 Causes EDSP2 And SEMDJL1 Pathway (1309217); Defective B3GAT3 Causes JDSSDHD Pathway (1269015); Defective B4GALT7 Causes EDS, Progeroid Type Pathway (1269014); Defective CHST14 Causes EDS, Musculocontractural Type Pathway (1269018); Defective CHST3 Causes SEDCJD Pathway (1269017)

This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients. [provided by RefSeq, Nov 2015]

DCN: May affect the rate of fibrils formation. Defects in DCN are the cause of congenital stromal corneal dystrophy (CSCD). Corneal dystrophies are inherited, bilateral, primary alterations of the cornea that are not associated with prior inflammation or secondary to systemic disease. Most show autosomal dominant inheritance. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. 5 isoforms of the human protein are produced by alternative splicing. Protein type: Extracellular matrix; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 12q21.33. Cellular Component: cytoplasm; extracellular matrix; extracellular region; extracellular space; Golgi lumen; lysosomal lumen. Molecular Function: protein binding; protein kinase inhibitor activity. Biological Process: chondroitin sulfate biosynthetic process; chondroitin sulfate catabolic process; cytokine and chemokine mediated signaling pathway; dermatan sulfate biosynthetic process; extracellular matrix disassembly; extracellular matrix organization and biogenesis; glycosaminoglycan metabolic process; negative regulation of angiogenesis; negative regulation of JAK-STAT cascade; negative regulation of protein kinase activity; organ morphogenesis; positive regulation of autophagy; positive regulation of macroautophagy; positive regulation of mitochondrial depolarization; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of transcription from RNA polymerase II promoter. Disease: Corneal Dystrophy, Congenital Stromal

0.06 mL

215 USD

0.12 mL

330

0.2 mL

500