antibody

Mouse anti Human SerpinA7 Monoclonal Antibody

MBS2543539

0.06 mL

215 USD

monoclonal

mouse

nonconjugated

ELISA, enzyme immunoassay

Antibody

Mouse anti Human SerpinA7 Monoclonal Antibody

[SerpinA7]

[SERPINA7, partial; Thyroxine-binding globulin; thyroxine-binding globulin; serpin family A member 7; Serpin A7; T4-binding globulin]

[SerpinA7]

[SERPINA7; SERPINA7; TBG; TBGQTL; TBG]

THBG_HUMAN

Monoclonal

IgG1

Mouse

Human

Store at -20°C, Avoid freeze/thaw cycles

ELISA (EIA)

ELISA: 1:1000-1:2000

Immunogen: Recombinant Human SerpinA7 protein. Buffer: PBS with 0.05% sodium azide, 30% glycerol and 5% trehalose

Produce: This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Serpin A7. The IgG fraction of the cell culture supertanant was purified by protein A affinity chromatography.

Thyroxine-binding globulin, also known as T4-binding globulin, Serpin A7 and TBG, is a secreted protein which belongs to the serpin family. TBG is synthesized primarily in the liver as a 54 kDa protein.TBG is genomically a serpin, although it has no inhibitory function like many other members of this class of proteins. TBG binds thyroid hormone in circulation. It is one of three proteins (along with transthyretin and albumin) responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3’-triiodothyronine (T3) in the bloodstream. Of these three proteins, TBG has the highest affinity for T4 and T3, but is present in the lowest concentration. Despite its low concentration, TBG carries the majority of T4 in serum. Due to the very low serum concentration of T4 and T3, TBG is rarely more than 25% saturated with its ligand. Unlike transthyretin and albumin, TBG has a single binding site for T4/T3. TBG tests are sometimes used in finding the reason for elevated or diminished levels of thyroid hormone.

823672780

Thyroid Hormone Synthesis Pathway (835410); Thyroid Hormone Synthesis Pathway (839541)

There are three proteins including thyroxine-binding globulin (TBG), transthyretin and albumin responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3'-triiodothyronine (T3) in the bloodstream. This gene encodes the major thyroid hormone transport protein, TBG, in serum. It belongs to the serpin family in genomics, but the protein has no inhibitory function like many other members of the serpin family. Mutations in this gene result in TGB deficiency, which has been classified as partial deficiency, complete deficiency, and excess, based on the level of serum TBG. Alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of these variants has not been determined.[provided by RefSeq, Jun 2012]

SERPINA7: Major thyroid hormone transport protein in serum. Defects in SERPINA7 are a cause of thyroxine-binding globulin deficiency (TBG deficiency). Mutations in the SERPINA7 gene can result as a whole spectrum of deficiencies, characterized by either reduced or increased TBG levels in the serum. Patients show, respectively, reduced or elevated protein- bound iodine but are euthyroid. Belongs to the serpin family. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: Xq22.2. Molecular Function: serine-type endopeptidase inhibitor activity. Disease: Thyroxine-binding Globulin Quantitative Trait Locus

0.06 mL

215 USD

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