MASP2 Polyclonal Antibody | MyBioSource MBS2542755 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

MASP2 Polyclonal Antibody

catalog :

MBS2542755

quantity :

0.02 mL

price :

110 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

Immunohistochemistry of paraffin-embedded Human liver cancer tissue using MASP2 Polyclonal Antibody at dilution 1:35

image 2 :

Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using MASP2 Polyclonal Antibody at dilution 1:35

product information

catalog number :

MBS2542755

products type :

Antibody

products full name :

MASP2 Polyclonal Antibody

products short name :

[MASP2]

products name syn :

[sMAP; MAP19; MASP-2; MASP1P1]

other names :

[mannan-binding lectin serine protease 2 isoform 2; Mannan-binding lectin serine protease 2; mannan-binding lectin serine protease 2; mannan binding lectin serine peptidase 2; MBL-associated serine protease 2; Mannose-binding protein-associated serine protease 2; MASP-2]

products gene name :

[MASP2]

other gene names :

[MASP2; MASP2; sMAP; MAP19; MASP-2; MASP1P1; MASP-2]

uniprot entry name :

MASP2_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

185

purity :

Antigen Affinity Purification

concentration :

1mg/mL

storage stability :

Store at -20°C. Avoid freeze/thaw cycles.

tested application :

ELISA (EIA), Immunohistochemistry (IHC)

app notes :

ELISA: 1:2000-5000. IHC: 1:25-100

image1 heading :

Immunohistochemistry (IHC)

image2 heading :

Immunohistochemistry (IHC)

other info1 :

Immunogen: Synthetic peptide of human MASP2. Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3

products description :

The Ra-reactive factor (RARF) is a complement-dependent bactericidal factor that binds to the Ra and R2 polysaccharides expressed by certain enterobacteria. Alternate splicing of this gene results in two transcript variants encoding two RARF components that are involved in the mannan-binding lectin pathway of complement activation. The longer isoform is cleaved into two chains which form a heterodimer linked by a disulfide bond. The encoded proteins are members of the trypsin family of peptidases.

ncbi gi num :

21264361

ncbi acc num :

NP_006601

ncbi gb acc num :

NM_139208.2

ncbi pathways :

Complement Activation Pathway (198823); Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Complement Cascade Pathway (1269241); Creation Of C4 And C2 Activators Pathway (1269243); Ficolins Bind To Repetitive Carbohydrate Structures On The Target Cell Surface Pathway (1269245); Immune System Pathway (1269170); Initial Triggering Of Complement Pathway (1269242); Innate Immune System Pathway (1269203)

ncbi summary :

This gene encodes a member of the peptidase S1 family of serine proteases. The encoded preproprotein is proteolytically processed to generate A and B chains that heterodimerize to form the mature protease. This protease cleaves complement components C2 and C4 in order to generate C3 convertase in the lectin pathway of the complement system. The encoded protease also plays a role in the coagulation cascade through cleavage of prothrombin to form thrombin. Myocardial infarction and acute stroke patients exhibit reduced serum concentrations of the encoded protein. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]

uniprot summary :

MASP2: Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase. Defects in MASP2 are the cause of MASP2 deficiency (MASPD). MASPD is a disorder that results in autoimmune manifestations, recurrent severe infections, and chronic inflammatory disease. Belongs to the peptidase S1 family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: EC 3.4.21.104; Protease; Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 1p36.3-p36.2. Cellular Component: extracellular region; extracellular space. Molecular Function: calcium-dependent protein binding; complement component C4b binding; peptidase activity; protein binding; serine-type endopeptidase activity. Biological Process: complement activation; complement activation, lectin pathway. Disease: Masp2 Deficiency

size1 :

0.02 mL

price1 :

110 USD

size2 :

0.06 mL

price2 :

150

size3 :

0.12 mL

price3 :

225

size4 :

0.2 mL

price4 :

360

more info or order :

MyBioSource product webpage