antibody

IL17A Monoclonal Antibody

MBS2542255

0.06 mL

220 USD

monoclonal

mouse

nonconjugated

[4679]

western blot, ELISA, enzyme immunoassay

Antibody

IL17A Monoclonal Antibody

[IL17A]

[CTLA 8; CTLA-8; CTLA8; Cytotoxic T lymphocyte associated antigen 8; Cytotoxic T lymphocyte associated protein 8; Cytotoxic T lymphocyte associated serine esterase 8; Cytotoxic T-lymphocyte-associated antigen 8; IL 17A; IL-17; IL-17A; IL17; IL17; Il17a; Interleukin 17 (cytotoxic T lymphocyte associated serine esterase 8); Interleukin 17A; Interleukin-17A; Interleukin17; Interleukin17A; OTTHUMP00000016597; OTTMUSP00000046003]

[interleukin-17A; Interleukin-17A; interleukin-17A; interleukin 17A; Cytotoxic T-lymphocyte-associated antigen 8; CTLA-8]

[IL17A]

[IL-17]

[IL17A; IL17A; IL17; CTLA8; IL-17; CTLA-8; IL-17A; CTLA8; IL17; IL-17; IL-17A; CTLA-8]

Monoclonal

IgG1

[4679]

Mouse

Human

155

Protein G purification

PBS with 0.02% sodium azide, 50% glycerol, PH7.3

Store at -20°C. Avoid freeze / thaw cycles.

Western Blot (WB), ELISA (EIA)

WB: 1:200-1:2000

Western Blot (WB)

Immunogen: Fusion protein of IL-17. Calculated MW: 15aa, 18kDa. Observed MW: 18kDa

Conjugation: Unconjugated

Cancer; Immunology

IL17A, also named as IL-17, is a proinflammatory cytokine. IL-17, synthesized only by memory T cells and natural killer cells, has pleiotropic effects, mainly in the recruitment and activation of neutrophils. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The IL-17 receptor is a type I transmembrane protein, that is widely expressed on epithelial cells, fibroblasts, B and T cells, and monocytic cells. In psoriatic skin lesions, both Th17 cells and their downstream effector molecules, e.g. IL-17 and IL-22, are highly increased.

4504651

NP_002181.1

NM_002190.2

Q16552

Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); IL23-mediated Signaling Events Pathway (138000); IL27-mediated Signaling Events Pathway (137929); Inflammatory Bowel Disease Pathway (842771); Rheumatoid Arthritis Pathway (200309); Rheumatoid Arthritis Pathway (200269); TCR Signaling Pathway (198862)

The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008]

Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines (PubMed:8676080).

0.06 mL

220 USD

0.12 mL

290

0.2 mL

435