antibody

P-Cadherin Monoclonal Antibody

MBS2542139

0.06 mL

220 USD

monoclonal

mouse

nonconjugated

western blot, ELISA, immunohistochemistry, enzyme immunoassay

Antibody

P-Cadherin Monoclonal Antibody

[P-Cadherin]

[CADH3; Cadherin 3; Cadherin 3 precursor; Cadherin 3 type 1; Cadherin-3; Cadp; Calcium dependent adhesion protein placental; CDH 3; CDH3; CDH3 protein; CDHP; HJMD; P cadherin (placental); P-cadherin; Placental cadherin]

[cadherin-3 isoform 2; Cadherin-3; cadherin-3; cadherin 3; Placental cadherin; P-cadherin]

[PCAD]

[CDH3]

[CDH3; CDH3; CDHP; HJMD; PCAD; CDHP; P-cadherin]

Monoclonal

IgG1

Mouse

Human

784

Protein G purification

PBS with 0.02% sodium azide, 50% glycerol, PH7.3

Store at -20 degree C. Avoid freeze / thaw cycles.

Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

WB 1:500-1:5000. IHC 1:50-1:500

Western Blot (WB)

Immunogen: Fusion protein of CDH3

Note: Centrifuge before opening to ensure complete recovery of vial contents.

Cancer; Neuroscience; Signal transduction

Cadherins are a family of transmembrane glycoproteins that mediate calcium-dependent cell-cell adhesion and play an important role in the maintenance of normal tissue architecture. P-cadherin (placental cadherin),also known as CDH3 (cadherin 3),is a classical member of the cadherin superfamily which also include E-,N-,R-,and B-cadherins. Aberrant expression of P-cadherin has been reported in many cancers,including breast,gastric,endometrial,ovarian,and prostate cancer.

953953841

NP_001304124.1

NM_001317195.1

P22223

Calculated MW: 829aa, 91kDa. Observed MW: 120kDa

Adherens Junctions Interactions Pathway (1270234); Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480); Cell Junction Organization Pathway (1270232); Cell-Cell Communication Pathway (1270231); Cell-cell Junction Organization Pathway (1270233)

This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a gene cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene are associated with hypotrichosis with juvenile macular dystrophy and ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome (EEMS). [provided by RefSeq, Nov 2015]

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

0.06 mL

220 USD

0.12 mL

290

0.2 mL

435