antibody

Neurofilament Monoclonal Antibody

MBS2541999

0.06 mL

220 USD

monoclonal

mouse

nonconjugated

human, mouse, rat

western blot, ELISA, immunohistochemistry, enzyme immunoassay

Antibody

Neurofilament Monoclonal Antibody

[Neurofilament]

[68 kDa neurofilament protein,NEFL,Neurofilament L,NF68,NFL,NF-L]

[neurofilament light polypeptide; Neurofilament light polypeptide; neurofilament light polypeptide; neurofilament light; 68 kDa neurofilament protein; Neurofilament triplet L protein]

[NF-L]

[NEFL; NEFL; NFL; NF-L; NF68; CMT1F; CMT2E; CMTDIG; PPP1R110; NF68; NFL; NF-L]

Monoclonal

IgG1

Mouse

Human, Mouse, Rat

543

Protein G purification

PBS with 0.02% sodium azide, 50% glycerol, PH7.3

Store at -20 degree C. Avoid freeze / thaw cycles.

Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

WB: 1:500-1:5000. IHC: 1:20-1:200

Western Blot (WB)

Immunogen: Fusion protein of NF-L

Cancer; Developmental biology; Neuroscience; Signal transduction; Stem cells

NEFL, also named as NF68 and NFL, belongs to the intermediate filament family. Neurofilaments are the 10nm intermediate filaments found specifically in neurons. They are a major component of the cell's cytoskeleton, and provide support for normal axonal radial growth. Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. The names given to the three major neurofilament subunits are based upon the apparent molecular weight of the mammalian subunits on SDS-PAGE:NF-L, 65-68kd; NF-M, 145-160kd and NF-H, 200-220kd. This antibody is specific to NEFL. It has a very weak reaction to NEFM.

105990539

NP_006149.2

NM_006158.4

P07196

Calculated: 543aa, 62kDa. Observed: 65kDa

Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway (161033); Amyotrophic Lateral Sclerosis (ALS) Pathway (920975); Amyotrophic Lateral Sclerosis (ALS) Pathway (83099); Amyotrophic Lateral Sclerosis (ALS) Pathway (511); CREB Phosphorylation Through The Activation Of CaMKII Pathway (161040); CREB Phosphorylation Through The Activation Of Ras Pathway (161036); Neuronal System Pathway (106513); Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Pathway (106534); Post NMDA Receptor Activation Events Pathway (161035); Ras Activation Uopn Ca2+ Infux Through NMDA Receptor Pathway (161037)

Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y. [provided by RefSeq, Oct 2008]

Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber.

0.06 mL

220 USD

0.12 mL

290

0.2 mL

435