antibody

IL19 Monoclonal Antibody

MBS2541949

0.06 mL

220 USD

monoclonal

mouse

nonconjugated

[257]

western blot, ELISA, immunohistochemistry, enzyme immunoassay

Antibody

IL19 Monoclonal Antibody

[IL19]

[IL 10C,IL 19,IL19,interleukin 19,MDA1,NG.1,ZMDA1]

[interleukin-19 isoform 2; Interleukin-19; interleukin-19; interleukin 19; Melanoma differentiation-associated protein-like protein; NG.1]

[IL19]

[IL-19]

[IL19; IL19; MDA1; NG.1; ZMDA1; IL-10C; ZMDA1; IL-19]

Monoclonal

IgG1

[257]

Mouse

Human

177

Protein G purification

PBS with 0.02% sodium azide, 50% glycerol, PH7.3

Store at -20 degree C. Avoid freeze / thaw cycles.

Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

WB 1:500-1:5000. IHC 1:20-1:200

Western Blot (WB)

Immunogen: Fusion protein of IL-19

Note: Centrifuge before opening to ensure complete recovery of vial contents.

Immunology

IL-19,a member of the IL-10 cytokine family,is expressed in epithelial cells,endothelial cells,and macrophages. It can bind the interleukin-20 receptor complex IL-20R1/IL-20R2 and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). IL-19 induces IL-6 and TNF-alpha production in monocytes. It also induces cell apoptosis and reactive oxygen species production in monocytes, which suggests a role of this cytokine in inflammatory responses. It is upregulated in monocytes following stimulation with lipopolysaccharide (LPS), and granulocyte-macrophage colony-stimulating factor (GM-CSF). IL-19 alters the balance of Th1 and Th2 cells in favor of Th2 cells. IL-19 contributes to a range of diseases and disorders,such as breast cancer,squamous cell carcinoma of the skin,asthma,endotoxic shock,uremia,psoriasis,rheumatoid arthritis,and periodontal and vascular disease.

30795208

NP_037503.2

NM_013371.3

Q9UHD0

Calculated MW: 177aa, 20kDa. Observed MW: 22kDa

Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); IL23-mediated Signaling Events Pathway (138000); Jak-STAT Signaling Pathway (83077); Jak-STAT Signaling Pathway (488)

The protein encoded by this gene is a cytokine that belongs to the IL10 cytokine subfamily. This cytokine is found to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described. [provided by RefSeq, Jul 2008]

May play some important roles in inflammatory responses. Up-regulates IL-6 and TNF-alpha and induces apoptosis ().

0.06 mL

220 USD

0.12 mL

290

0.2 mL

435