catalog number :
MBS2540903
products full name :
POP4 Polyclonal Antibody
products short name :
[POP4]
products name syn :
[RPP29]
other names :
[POP4; Ribonuclease P protein subunit p29; ribonuclease P protein subunit p29; POP4 homolog, ribonuclease P/MRP subunit]
products gene name :
[POP4]
other gene names :
[POP4; POP4; RPP29; RPP29; hPOP4]
uniprot entry name :
RPP29_HUMAN
reactivity :
Human, Mouse, Rat
purity :
Affinity Purification
storage stability :
Store at -20 degree C. Avoid freeze/thaw cycles.
tested application :
Western Blot (WB), Immunohistochemistry (IHC)
app notes :
WB 1:200-1:2000, IHC 1:50-1:200
image1 heading :
Western Blot (WB)
image2 heading :
Immunohistochemistry
products description :
Background: This gene encodes one of the protein subunits of the small nucleolar ribonucleoprotein complexes: the endoribonuclease for mitochondrial RNA processing complex and the ribonuclease P complex. The encoded protein is localized to the nucleus and associates directly with the RNA component of these complexes. This protein is involved in processing of precursor RNAs. Alternative splicing results in multiple transcript variants.
ncbi mol weight :
Calculated MW: 25kDa. Observed MW: 25kDa
ncbi pathways :
Gene Expression Pathway (1269649); RNA Transport Pathway (177876); RNA Transport Pathway (175229); Ribosome Biogenesis In Eukaryotes Pathway (199378); Ribosome Biogenesis In Eukaryotes Pathway (199266); TRNA Processing Pathway (1309088); TRNA Processing In The Nucleus Pathway (1309089)
ncbi summary :
This gene encodes one of the protein subunits of the small nucleolar ribonucleoprotein complexes: the endoribonuclease for mitochondrial RNA processing complex and the ribonuclease P complex. The encoded protein is localized to the nucleus and associates directly with the RNA component of these complexes. This protein is involved in processing of precursor RNAs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]
uniprot summary :
POP4: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. May function with RPP38 to coordinate the nucleolar targeting and/or assembly of RNase P. Belongs to the eukaryotic/archaeal RNase P protein component 1 family. Protein type: EC 3.1.26.5; Nucleolus; RNA processing; RNA-binding; Ribonuclease. Chromosomal Location of Human Ortholog: 19q12. Cellular Component: nucleoplasm; ribonuclease P complex. Molecular Function: protein binding; ribonuclease MRP activity; ribonuclease P RNA binding; RNA binding. Biological Process: tRNA 5'-leader removal; tRNA processing