catalog number :
MBS2540419
products type :
Assay Kit
products full name :
Nitric Oxide Synthase (NOS) assay kit (Colormetric method)
products short name :
[Nitric Oxide Synthase (NOS)]
other names :
[nitric oxide synthase, partial; Nitric oxide synthase, endothelial; nitric oxide synthase, endothelial; nitric oxide synthase 3; Constitutive NOS; cNOS; EC-NOS; Endothelial NOS; eNOS; NOS type III; NOSIII]
products gene name :
[NOS]
other gene names :
[NOS3; NOS3; eNOS; ECNOS; cNOS; eNOS; NOSIII]
uniprot entry name :
NOS3_HUMAN
storage stability :
This product has an approximately 2-2.5 month shelf life upon receipt. Please refer to the expiration date on the kit box.
other info1 :
Samples: Microorganisms, Medicine, Food, Beverage, Cosmetics And Other Samples Can Be Tested By This Kit Too
ncbi mol weight :
67,876 Da
ncbi pathways :
ACE Inhibitor Pathway (198763); AGE-RAGE Signaling Pathway In Diabetic Complications (1319988); AGE-RAGE Signaling Pathway In Diabetic Complications (1319775); AGE/RAGE Pathway (698754); Angiogenesis Pathway (198772); Angiopoietin Receptor Tie2-mediated Signaling Pathway (137917); Arginine And Proline Metabolism Pathway (82957); Arginine And Proline Metabolism Pathway (323); Arginine Biosynthesis Pathway (82943); Arginine Biosynthesis Pathway (306)
ncbi summary :
Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide is synthesized from L-arginine by nitric oxide synthases. Variations in this gene are associated with susceptibility to coronary spasm. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016]
uniprot summary :
eNOS: endothelial constitutive nitric oxide synthase. Synthesizes nitric oxide (NO) from arginine and oxygen, which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. Induced in humans by caloric restriction. Stimulated by calcium/calmodulin. Inhibited by NOSIP and NOSTRIN. Protein type: Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase. Chromosomal Location of Human Ortholog: 7q36. Cellular Component: caveola; cytoplasm; cytosol; Golgi membrane; nucleus; plasma membrane. Molecular Function: actin monomer binding; heme binding; nitric-oxide synthase activity; protein binding. Biological Process: arginine catabolic process; blood vessel remodeling; cell redox homeostasis; endothelial cell migration; mitochondrion organization and biogenesis; negative regulation of blood pressure; negative regulation of cell proliferation; negative regulation of muscle hyperplasia; nitric oxide biosynthetic process; nitric oxide mediated signal transduction; positive regulation of angiogenesis; positive regulation of guanylate cyclase activity; positive regulation of vasodilation; regulation of blood vessel size; regulation of nitric-oxide synthase activity; regulation of systemic arterial blood pressure by endothelin; removal of superoxide radicals; smooth muscle hyperplasia. Disease: Alzheimer Disease; Hypertension, Essential; Preeclampsia/eclampsia 1; Stroke, Ischemic