catalog number :
MBS2540413
products type :
Assay Kit
products full name :
Catalase (CAT) assay kit (Visible light method)
products short name :
[Catalase (CAT)]
other names :
[catalase; Catalase; catalase; catalase]
products gene name :
[CAT]
other gene names :
[CAT; CAT]
uniprot entry name :
CATA_HUMAN
other info1 :
Samples: Samples, Such As Juice, Honey, Seminal Plasma, Tissues, Etc
products description :
Principle of the Assay: The product of fructose and matrix solution has a maximum absorption peak at 285 nm. The fructose content can be calculated indirectly by measuring the OD value at 285 nm.
ncbi gb acc num :
NM_001752.3
ncbi mol weight :
59,756 Da
ncbi pathways :
Amyotrophic Lateral Sclerosis (ALS) Pathway (83099); Amyotrophic Lateral Sclerosis (ALS) Pathway (920975); Amyotrophic Lateral Sclerosis (ALS) Pathway (511); Carbon Metabolism Pathway (814926); Carbon Metabolism Pathway (817567); Cellular Responses To Stress Pathway (1270414); DNA Damage Response (only ATM Dependent) Pathway (198827); Detoxification Of Reactive Oxygen Species Pathway (1270420); Folate Metabolism Pathway (198833); FoxO Family Signaling Pathway (138036)
ncbi summary :
This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene. [provided by RefSeq, Oct 2009]
uniprot summary :
Catalase: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells. Homotetramer. Belongs to the catalase family. Protein type: Amino Acid Metabolism - tryptophan; Apoptosis; EC 1.11.1.6; Endoplasmic reticulum; Energy Metabolism - methane; Hydrolase; Mitochondrial; Oxidoreductase. Chromosomal Location of Human Ortholog: 11p13. Cellular Component: focal adhesion; intracellular membrane-bound organelle; membrane; mitochondrion; peroxisomal matrix; peroxisomal membrane; peroxisome. Molecular Function: antioxidant activity; catalase activity; enzyme binding; heme binding; NADP binding; oxidoreductase activity, acting on peroxide as acceptor; protein homodimerization activity; receptor binding. Biological Process: hydrogen peroxide catabolic process; negative regulation of apoptosis; osteoblast differentiation; protein homotetramerization; protein tetramerization; purine nucleotide catabolic process; response to hydrogen peroxide; response to reactive oxygen species; UV protection. Disease: Acatalasemia