ERBB2 Monoclonal Antibody | MyBioSource MBS2540273 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

ERBB2 Monoclonal Antibody

catalog :

MBS2540273

quantity :

0.06 mL

price :

220 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human

application :

ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS2540273

products type :

Antibody

products full name :

ERBB2 Monoclonal Antibody

products short name :

[ERBB2]

products name syn :

[CD340, ERBB2, HER 2, HER 2/neu, HER2, MLN 19, MLN19, NEU, NGL, p185, p185erbB2, Protooncogene c ErbB 2, Proto oncogene Neu, TKR1]

other names :

[receptor tyrosine-protein kinase erbB-2 isoform b; Receptor tyrosine-protein kinase erbB-2; receptor tyrosine-protein kinase erbB-2; erb-b2 receptor tyrosine kinase 2; Metastatic lymph node gene 19 protein; MLN 19; Proto-oncogene Neu; Proto-oncogene c-ErbB-2; Tyrosine kinase-type cell surface receptor HER2; p185erbB2; CD_antigen: CD340]

products gene name :

[ERBB2]

other gene names :

[ERBB2; ERBB2; NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu; HER2; MLN19; NEU; NGL; MLN 19]

clonality :

Monoclonal

isotype :

IgG2b

host :

Mouse

reactivity :

Human

sequence length :

1225

purity :

Protein A purification

form :

PBS with 0.02% sodium azide, 50% glycerol, pH 7.3

storage stability :

Store at -20°C. Avoid freeze / thaw cycles.

tested application :

Immunohistochemistry (IHC), ELISA (EIA)

app notes :

Immunohystochemistry: 1:50-1:400

other info1 :

Immunogen: Fusion protein of HER2/ErbB2

products categories :

Cancer; Immunology; Signal transduction; Tags & Cell Markers

products description :

HER2, also known as ErbB2 and Neu, is a 185-kDa transmembrane glycoprotein that is a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. It has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen activated protein kinase and phosphatidylinositol-3 kinase. Amplification and/or overexpression of HER2 have been reported in numerous cancers, including breast and ovarian tumors. HER2 is a therapeutic target for the treatment of breast cancer and other carcinomas.

ncbi gi num :

54792098

ncbi acc num :

NP_001005862.1

ncbi gb acc num :

NM_001005862.2

uniprot acc num :

P04626

ncbi mol weight :

1255aa, 138kDa

ncbi pathways :

Adaptive Immune System Pathway (366160); Adherens Junction Pathway (83070); Adherens Junction Pathway (481); Alpha6-Beta4 Integrin Signaling Pathway (198807); Axon Guidance Pathway (105688); Bladder Cancer Pathway (83115); Bladder Cancer Pathway (527); Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Constitutive PI3K/AKT Signaling In Cancer Pathway (685535)

ncbi summary :

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]

uniprot summary :

Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.

size1 :

0.06 mL

price1 :

220 USD

size2 :

0.12 mL

price2 :

290

size3 :

0.2 mL

price3 :

435

more info or order :

MyBioSource product webpage