IL2 Polyclonal Antibody | MyBioSource MBS2540143 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

IL2 Polyclonal Antibody

catalog :

MBS2540143

quantity :

0.02 mL

price :

110 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

immunohistochemistry

more info or order :

MyBioSource product webpage

image

image 1 :

Immunohistochemistry of paraffin-embedded Rat heart using IL2 Polyclonal Antibody at dilution of 1:50

image 2 :

Immunohistochemistry of paraffin-embedded Mouse lung using IL2 Polyclonal Antibody at dilution of 1:50

product information

catalog number :

MBS2540143

products type :

Antibody

products full name :

IL2 Polyclonal Antibody

products short name :

[IL2]

products name syn :

[Aldesleukin; IL 2; IL2; interleukin 2; lymphokine; T cell growth factor; TCGF; POIL2; OTTHUMP00000164090]

other names :

[interleukin-2; Interleukin-2; interleukin-2; interleukin 2; T-cell growth factor; TCGF; INN: Aldesleukin]

products gene name :

[IL2]

other gene names :

[IL2; IL2; IL-2; TCGF; lymphokine; IL-2; TCGF]

uniprot entry name :

IL2_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Rat, Mouse

sequence length :

153

purity :

Affinity purification

storage stability :

Store at -20 degree C. Avoid freeze/ thaw cycles.

tested application :

Immunohistochemistry (IHC)

app notes :

Immunohistochemistry: 1:50-1:100

image1 heading :

Immunohistochemistry (IHC)

image2 heading :

Immunohistochemistry (IHC)

other info1 :

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

other info2 :

Immunogen: Recombinant Mouse Interleukin-2 protein. Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-48544 / sc-34796 / sc-48545 / sc-7896

products categories :

Cancer

products description :

Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.

ncbi gi num :

28178861

ncbi acc num :

NP_000577.2

ncbi gb acc num :

NM_000586.3

uniprot acc num :

P60568

ncbi pathways :

ARMS-mediated Activation Pathway (1269471); AhR Pathway (755436); Allograft Rejection Pathway (83123); Allograft Rejection Pathway (535); Autoimmune Thyroid Disease Pathway (83121); Autoimmune Thyroid Disease Pathway (533); Axon Guidance Pathway (1270303); Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway (137993); Calcium Signaling In The CD4+ TCR Pathway (137941); Chagas Disease (American Trypanosomiasis) Pathway (147809)

ncbi summary :

The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008]

uniprot summary :

IL2: Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells. A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17. Belongs to the IL-2 family. Protein type: Cytokine; Secreted, signal peptide; Secreted; Oncoprotein. Chromosomal Location of Human Ortholog: 4q26-q27. Cellular Component: extracellular region; extracellular space. Molecular Function: cytokine activity; growth factor activity; interleukin-2 receptor binding; kinase activator activity; Ras guanyl-nucleotide exchange factor activity. Biological Process: cell adhesion; cell-cell signaling; immune response; MAPKKK cascade; natural killer cell activation; negative regulation of apoptosis; negative regulation of B cell apoptosis; positive regulation of activated T cell proliferation; positive regulation of B cell proliferation; positive regulation of cell growth; positive regulation of cell proliferation; positive regulation of inflammatory response; positive regulation of interleukin-17 production; positive regulation of tissue remodeling; positive regulation of tyrosine phosphorylation of Stat5 protein; T cell differentiation

size1 :

0.02 mL

price1 :

110 USD

size2 :

0.06 mL

price2 :

150

size3 :

0.12 mL

price3 :

225

size4 :

0.2 mL

price4 :

360

more info or order :

MyBioSource product webpage