NOTCH2 Polyclonal Antibody | MyBioSource MBS2540022 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

NOTCH2 Polyclonal Antibody

catalog :

MBS2540022

quantity :

0.06 mL

price :

150 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of extracts of various cell lines, using NOTCH2 antibody.

image 2 :

Immunohistochemistry of paraffin-embedded human stomach using NOTCH2 antibody.

image 3 :

Immunohistochemistry of paraffin-embedded mouse brain using NOTCH2 antibody.

product information

catalog number :

MBS2540022

products type :

Antibody

products full name :

NOTCH2 Polyclonal Antibody

products short name :

[NOTCH2]

products name syn :

[hN2; AGS2; HJCYS]

other names :

[neurogenic locus notch homolog protein 2 isoform 2; Neurogenic locus notch homolog protein 2; neurogenic locus notch homolog protein 2; notch 2]

products gene name :

[NOTCH2]

other gene names :

[NOTCH2; NOTCH2; hN2; AGS2; HJCYS; N2ICD]

uniprot entry name :

NOTC2_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse

sequence length :

1235

purity :

Affinity purification

form :

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

storage stability :

Store at -20 degree C. Avoid freeze/ thaw cycles.

tested application :

Western Blot (WB), Immunohistochemistry (IHC)

app notes :

WB: 1:500 - 1:2000. IHC: 1:100 - 1:200

image1 heading :

Western Blot (WB)

image2 heading :

Immunohistochemistry (IHC)

image3 heading :

Immunohistochemistry (IHC)

other info1 :

Immunogen: Recombinant protein of human NOTCH2

other info2 :

Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-32344 / sc-32346 / sc-5545

products description :

This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factorlike (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene.

ncbi gi num :

317008611

ncbi acc num :

NP_001186930.1

ncbi gb acc num :

NM_001200001.1

uniprot acc num :

Q04721

ncbi mol weight :

Calculated MW: 265kDa. Observed MW: 120kDa

ncbi pathways :

Defective LFNG Causes SCDO3 Pathway (1383053); Delta-Notch Signaling Pathway (198879); Disease Pathway (1268854); Diseases Associated With O-glycosylation Of Proteins Pathway (1383049); Diseases Of Glycosylation Pathway (1269010); Dorso-ventral Axis Formation Pathway (114227); Dorso-ventral Axis Formation Pathway (472); Gene Expression Pathway (1269649); Generic Transcription Pathway (1269650); MicroRNAs In Cancer Pathway (852705)

ncbi summary :

This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

uniprot summary :

Notch 2: a member of the Notch family. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. Affects the implementation of differentiation, proliferation and apoptotic programs. Cleaved in the trans-Golgi network and presented on the cell surface as a heterodimer. This protein functions as a receptor for the membrane bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. Protein type: Receptor, misc.; Membrane protein, integral; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 1p13-p11. Cellular Component: cell surface; endoplasmic reticulum membrane; extracellular region; Golgi membrane; integral to plasma membrane; membrane; nucleoplasm; nucleus; plasma membrane; receptor complex. Molecular Function: protein binding. Biological Process: apoptosis; bone remodeling; cell cycle arrest; cell fate determination; cell growth; hemopoiesis; marginal zone B cell differentiation; negative regulation of apoptosis; negative regulation of cell proliferation; Notch signaling pathway; organ morphogenesis; positive regulation of Ras protein signal transduction; regulation of transcription, DNA-dependent; stem cell maintenance; transcription initiation from RNA polymerase II promoter. Disease: Alagille Syndrome 2; Hajdu-cheney Syndrome

size1 :

0.06 mL

price1 :

150 USD

size2 :

0.12 mL

price2 :

225

size3 :

0.2 mL

price3 :

360

more info or order :

MyBioSource product webpage