Phospho-CREB-1 (S133) Polyclonal Antibody | MyBioSource MBS2539788 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Phospho-CREB-1 (S133) Polyclonal Antibody

catalog :

MBS2539788

quantity :

0.02 mL

price :

110 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

image

image 1 :

Western Blot analysis of various cells with Phospho-CREB-1 (Ser133) Polyclonal Antibody at dilution of 1:1000

image 2 :

Immunohistochemistry of paraffin-embedded Human uterus tissue with Phospho-CREB-1 (Ser133) Polyclonal Antibody at dilution of 1:200

image 3 :

Immunofluorescence analysis of Mouse lung tissue with Phospho-CREB-1 (Ser133) Polyclonal Antibody at dilution of 1:200

product information

catalog number :

MBS2539788

products type :

Antibody

products full name :

Phospho-CREB-1 (S133) Polyclonal Antibody

products short name :

[CREB-1]

products name syn :

[CREB1; Cyclic AMP-responsive element-binding protein 1; CREB-1; cAMP-responsive element-binding protein 1]

other names :

[cyclic AMP-responsive element-binding protein 1 isoform C; Cyclic AMP-responsive element-binding protein 1; cyclic AMP-responsive element-binding protein 1; cAMP responsive element binding protein 1]

products gene name :

[CREB-1]

other gene names :

[CREB1; CREB1; CREB; CREB-1; CREB-1; cAMP-responsive element-binding protein 1]

uniprot entry name :

CREB1_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

purity :

Affinity purification.

concentration :

1mg/mL

storage stability :

Store at -20°C. Avoid freeze / thaw cycles.

tested application :

WB, IHC-p-, IF, ELISA

app notes :

WB 1:500-1:2000. IHC 1:100-1:300. IF 1:100-1-1:300. ELISA 1:5000-1:20000

image1 heading :

Western Blot (WB)

image2 heading :

Immunohistochemistry (IHC)

image3 heading :

Immunofluorescence (IF)

other info1 :

Immunogen: Synthesized peptide derived from human CREB-1 around the phosphorylation site of S133. Buffer: PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol, pH7.4.

other info2 :

Calculated MW: 37 kDa. Observed MW: 37kDa

products categories :

Phospho Antibodies

products description :

This protein binds the cAMP response element (CRE), a sequence presentin many viral and cellular promoters. CREB stimulates transcription on binding to the CRE. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation.Implicated in synchronization of circadian rhythmicity.

ncbi gi num :

1003088836

ncbi acc num :

NP_001307722.1

ncbi gb acc num :

NM_001320793.1

ncbi pathways :

AKT Phosphorylates Targets In The Nucleus Pathway (1269190); AMPK Signaling Pathway (989139); AMPK Signaling Pathway (992181); ATF-2 Transcription Factor Network Pathway (138006); ATM Signaling Pathway (920969); Activated TLR4 Signalling Pathway (1269236); Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway (1268798); Adaptive Immune System Pathway (1269171); Adipogenesis Pathway (198832); Adrenergic Signaling In Cardiomyocytes Pathway (908257)

ncbi summary :

This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in several transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]

uniprot summary :

CREB: a transcription factor of the leucine zipper family of DNA binding proteins. Binds as a homodimer to the cAMP-responsive element (CRE). Phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Two splice-variant isoforms have been described. Protein type: Transcription factor; DNA-binding. Chromosomal Location of Human Ortholog: 2q34. Cellular Component: axon; mitochondrial matrix; nucleoplasm; nucleus. Molecular Function: enzyme binding; histone acetyltransferase binding; Hsp70 protein binding; identical protein binding; protein binding; RNA polymerase II transcription factor activity, enhancer binding; transcription cofactor activity; transcription factor activity. Biological Process: aging; axon guidance; circadian rhythm; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; innate immune response; lactation; memory; MyD88-dependent toll-like receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; nerve growth factor receptor signaling pathway; Notch signaling pathway; phosphoinositide-mediated signaling; phospholipase C activation; pituitary gland development; positive regulation of apoptosis; positive regulation of fat cell differentiation; positive regulation of hormone secretion; positive regulation of lipid biosynthetic process; positive regulation of multicellular organism growth; positive regulation of osteoclast differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of transcriptional preinitiation complex assembly; positive regulation of transforming growth factor-beta3 production; protein amino acid phosphorylation; protein stabilization; regulation of cell size; regulation of circadian rhythm; regulation of fibroblast proliferation; response to activity; response to glucagon stimulus; response to hypoxia; response to nicotine; response to organic substance; secretory granule organization and biogenesis; signal transduction; stress-activated MAPK cascade; synaptic transmission; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 5 signaling pathway; toll-like receptor 9 signaling pathway; toll-like receptor signaling pathway; transcription from RNA polymerase II promoter; transforming growth factor beta receptor signaling pathway; viral reproduction; visual learning. Disease: Histiocytoma, Angiomatoid Fibrous

size1 :

0.02 mL

price1 :

110 USD

size2 :

0.06 mL

price2 :

150

size3 :

0.12 mL

price3 :

225

size4 :

0.2 mL

price4 :

360

more info or order :

MyBioSource product webpage