antibody

Rhodopsin Polyclonal Antibody

MBS2539162

0.02 mL

110 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, ELISA, immunohistochemistry - paraffin section

Antibody

Rhodopsin Polyclonal Antibody

[Rhodopsin]

[RHO; OPN2; Rhodopsin; Opsin-2]

[rhodopsin; Rhodopsin; rhodopsin; rhodopsin; Opsin-2]

[RHO; RHO; RP4; OPN2; CSNBAD1; OPN2]

OPSD_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

Affinity Purification

1mg/mL

Store at -20°C. Avoid freeze / thaw cycles.

WB, IHC-p, ELISA

WB 1:500-2000. IHC 1:100-1:300. ELISA 1:5000

Western Blot (WB)

Immunogen: Synthesized peptide derived from human Rhodopsin around the non-phosphorylation site of S334. Calculated MW: 39 kDa. Observed MW: 42 kDa. Buffer: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol pH 7.4.

Retinitis pigmentosa is an inherited progressive disease which is a majorcause of blindness in western communities. It can be inherited as anautosomal dominant, autosomal recessive, or X-linked recessive disorder.In the autosomal dominant form,which comprises about 25% of totalcases, approximately 30% of families have mutations in the geneencoding the rod photoreceptor-specific protein rhodopsin. This is thetransmembrane protein which, when photoexcited, initiates the visualtransduction cascade. Defects in this gene are also one of the causes ofcongenital stationary night blindness.RHO (Rhodopsin) is a ProteinCoding gene. Diseases associated with RHO include Night Blindness,Congenital Stationary, Autosomal Dominant 1 and Retinitis Pigmentosa4, Autosomal Dominant Or Recessive. Among its related pathways are thevisual cycle I (vertebrates) and Phototransduction. GO annotations relatedto this gene include G-protein coupled receptor activity and photoreceptoractivity. An important paralog of this gene is OPN1SW

4506527

NP_000530.1

NM_000539.3

Activation Of The Phototransduction Cascade Pathway (1269628); Assembly Of The Primary Cilium Pathway (1268846); Cargo Trafficking To The Periciliary Membrane Pathway (1268848); Class A/1 (Rhodopsin-like Receptors) Pathway (1269545); G Alpha (i) Signalling Events Pathway (1269576); GPCR Downstream Signaling Pathway (1269574); GPCR Ligand Binding Pathway (1269544); GPCRs, Class A Rhodopsin-like Pathway (198886); Inactivation, Recovery And Regulation Of The Phototransduction Cascade Pathway (1269629); Integrated Breast Cancer Pathway (219801)

Retinitis pigmentosa is an inherited progressive disease which is a major cause of blindness in western communities. It can be inherited as an autosomal dominant, autosomal recessive, or X-linked recessive disorder. In the autosomal dominant form,which comprises about 25% of total cases, approximately 30% of families have mutations in the gene encoding the rod photoreceptor-specific protein rhodopsin. This is the transmembrane protein which, when photoexcited, initiates the visual transduction cascade. Defects in this gene are also one of the causes of congenital stationary night blindness. [provided by RefSeq, Jul 2008]

Rhodopsin: a G-protein coupled receptor. The light-absorbing visual pigment in Rod photoreceptor cells. Mediates vision in dim light. Consists of the apoprotein, opsin, covalently linked to cis-retinal. Defects in RHO are a cause of autosomal retinitis pigmentosa and congenital stationary night blindness. Protein type: Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral; Receptor, GPCR. Chromosomal Location of Human Ortholog: 3q21-q24. Cellular Component: Golgi apparatus; Golgi membrane; integral to plasma membrane; intercellular junction; photoreceptor inner segment; photoreceptor outer segment; plasma membrane; rough endoplasmic reticulum membrane. Molecular Function: G-protein coupled receptor activity; metal ion binding; photoreceptor activity; protein binding; retinal binding. Biological Process: absorption of visible light; G-protein coupled receptor protein signaling pathway; organelle organization and biogenesis; photoreceptor cell maintenance; phototransduction, visible light; protein amino acid phosphorylation; protein-chromophore linkage; red, far-red light phototransduction; regulation of rhodopsin mediated signaling; retina development in camera-type eye; retinoid metabolic process; rhodopsin mediated signaling; visual perception. Disease: Fundus Albipunctatus; Night Blindness, Congenital Stationary, Autosomal Dominant 1; Retinitis Pigmentosa 4

0.02 mL

110 USD

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150

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0.2 mL

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