antibody

TFEB Polyclonal Antibody

MBS2538354

0.02 mL

110 USD

polyclonal

rabbit

nonconjugated

human, mouse

western blot, ELISA, immunohistochemistry - paraffin section

Antibody

TFEB Polyclonal Antibody

[TFEB]

[TFEB; BHLHE35; Transcription factor EB; Class E basic helix-loop-helix protein 35; bHLHe35]

[transcription factor EB isoform 2; Transcription factor EB; transcription factor EB; transcription factor EB; Class E basic helix-loop-helix protein 35; bHLHe35]

[TFEB]

[TFEB; TFEB; TCFEB; BHLHE35; ALPHATFEB; BHLHE35; bHLHe35]

TFEB_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse

Affinity purification

Store at -20 degree C. Avoid freeze / thaw cycles.

WB, IHC-p, ELISA

WB: 1:500-1:2000. IHC 1:100-1:300 . ELISA 1:2000

Western Blot (WB)

Cancer

Background: TFEB (Transcription Factor EB) is a Protein Coding gene. Diseases associated with TFEB include Renal Cell Carcinoma, Papillary and Microphthalmia. Among its related pathways are Apoptosis and Autophagy and PI3K-AKT-mTOR signaling pathway and therapeutic opportunities. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein dimerization activity. An important paralog of this gene is MITF.

429836865

NP_001161299.2

NM_001167827.2

TFEB: Transcription factor that specifically recognizes and binds E-box sequences (3'-CANNTG-5'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T- cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta. Homodimer and heterodimer; with TFE3 or MITF. Belongs to the MiT/TFE family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: DNA-binding. Chromosomal Location of Human Ortholog: 6p21. Cellular Component: cytoplasm; nucleus. Molecular Function: protein dimerization activity; transcription factor activity. Biological Process: adaptive immune response; autophagy; embryonic placenta development; humoral immune response; lysosome organization and biogenesis; positive regulation of autophagy; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; transcription, DNA-dependent

0.02 mL

110 USD

0.06 mL

150

0.12 mL

225

0.2 mL

360