Mouse MMP-19 (Matrix Metalloproteinase 19) ELISA Kit | MyBioSource MBS2533493 product information

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product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Mouse MMP-19 (Matrix Metalloproteinase 19) ELISA Kit

catalog :

MBS2533493

quantity :

24-Strip-Wells

price :

215 USD

product information

catalog number :

MBS2533493

products type :

ELISA Kit

products full name :

Mouse MMP-19 (Matrix Metalloproteinase 19) ELISA Kit

products short name :

[Matrix Metalloproteinase 19]

other names :

[matrix metalloproteinase-19 isoform 1 preproprotein; Matrix metalloproteinase-19; matrix metalloproteinase-19; matrix metallopeptidase 19; Matrix metalloproteinase RASI; Matrix metalloproteinase-18; MMP-18]

products gene name :

[MMP-19]

other gene names :

[MMP19; MMP19; CODA; MMP18; RASI-1; MMP18; RASI; MMP-19; MMP-18]

uniprot entry name :

MMP19_HUMAN

reactivity :

Mouse

sequence length :

508

specificity :

This kit recognizes natural and some recombinant Mouse MMP-19. No Significant cross -reactivity or interference between Mouse MMP-19and analogues was observed.

storage stability :

Store at 4 degree C.

image1 heading :

Typical Testing Data/Standard Curve (for reference only)

other info1 :

Samples: Serum, Plasma, Biological Fluids. Assay Type: Sandwich. Detection Range: 0.313-20ng/mL. Sensitivity: Min: 0.188ng/mL; Max: 20ng/mL

products description :

Intended Uses: This ELISA kit applies to the invitro quantitative determination of MouseMMP-19concentrations in serum, plasma and other biological fluids. Principle of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to MMP-19. Standards or samples are added to the appropriate micro ELISA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for MMP-19and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain MMP-19, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of MMP-19.You can calculate the concentration of MMP-19in the samples by comparing the OD of the samples to the standard curve.

ncbi gi num :

4505213

ncbi acc num :

NP_002420.1

ncbi gb acc num :

NM_002429.5

ncbi mol weight :

33,793 Da

ncbi pathways :

Collagen Degradation Pathway (1270259); Degradation Of The Extracellular Matrix Pathway (1270257); Extracellular Matrix Organization Pathway (1270244); Matrix Metalloproteinases Pathway (198900)

ncbi summary :

This gene encodes a member of a family of proteins that are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded protein is secreted as an inactive proprotein, which is activated upon cleavage by extracellular proteases. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013]

uniprot summary :

MMP19: Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin. May play a role in pathological processes participating in rheumatoid arthritis (RA)-associated joint tissue destruction. Autoantigen anti-MMP19 are frequent in RA patients. Belongs to the peptidase M10A family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: EC 3.4.24.-; Secreted, signal peptide; Secreted; Protease. Chromosomal Location of Human Ortholog: 12q14. Cellular Component: extracellular region; proteinaceous extracellular matrix. Molecular Function: calcium ion binding; metalloendopeptidase activity; zinc ion binding. Biological Process: angiogenesis; cell differentiation; collagen catabolic process; extracellular matrix disassembly; extracellular matrix organization and biogenesis; luteolysis; ovarian follicle development; ovulation from ovarian follicle; proteolysis; response to cAMP; response to hormone stimulus. Disease: Cavitary Optic Disc Anomalies

size1 :

24-Strip-Wells

price1 :

215 USD

size2 :

48-Strip-Wells

price2 :

410

size3 :

96-Strip-Wells

price3 :

490

size4 :

5x96-Strip-Wells

price4 :

2040

size5 :

10x96-Strip-Wells

price5 :

3590