ELISA/assay

Human B-Cell Lymphoma 11A (Bcl11A) ELISA Kit

MBS2533302

24-Strip-Wells

215 USD

ELISA Kit

Human B-Cell Lymphoma 11A (Bcl11A) ELISA Kit

[Bcl11A]

[B-cell lymphoma/leukemia 11A isoform 3; B-cell lymphoma/leukemia 11A; B-cell lymphoma/leukemia 11A; B-cell CLL/lymphoma 11A; B-cell CLL/lymphoma 11A; COUP-TF-interacting protein 1; Ecotropic viral integration site 9 protein homolog; EVI-9; Zinc finger protein 856]

[BCL11A; BCL11A; EVI9; CTIP1; ZNF856; HBFQTL5; BCL11A-L; BCL11A-S; BCL11a-M; BCL11A-XL; CTIP1; EVI9; KIAA1809; ZNF856; BCL-11A; EVI-9]

BC11A_HUMAN

Human

243

This kit recognizes natural and recombinantHumanBcl11A. No significant cross-reactivity or interference between HumanBcl11A and analogues was observed.

Store at 4 degree C.

Typical Testing Data/Standard Curve (for reference only)

Samples: Serum, Plasma, Biological Fluids. Assay Type: Sandwich. Detection Range: 0.625-40ng/mL. Sensitivity: Min: 0.375ng/mL; Max: 40ng/mL

Intra-assay Precision: Intra -assay Precision (Precision within an assay): 3 samples with low, middle and high level Human Bcl11A were tested 20times on one plate, respectively. Inter-assay Precision: Inter-assay Precision (Precision between assays): 3 samples with low, middle and high level Human Bcl11A were tested on 3 different plates, 20replicates in each plate.

Intended Uses: This ELISA kit applies to the invitro quantitative determination of HumanBcl11Aconcentrations in serum, plasma and other biological fluids.

20336313

NP_612569.1

NM_138559.1

87,554 Da

This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Bcl-11A: Functions as a myeloid and B-cell proto-oncogene. May play important roles in leukemogenesis and hematopoiesis. An essential factor in lymphopoiesis, is required for B-cell formation in fetal liver. May function as a modulator of the transcriptional repression activity of ARP1. Chromosomal aberrations involving BCL11A may be a cause of lymphoid malignancies. Translocation t(2;14)(p13;q32.3) causes BCL11A deregulation and amplification. 6 isoforms of the human protein are produced by alternative splicing. Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor; C2H2-type zinc finger protein. Chromosomal Location of Human Ortholog: 2p16.1. Cellular Component: cytoplasm; nucleoplasm; nucleus. Molecular Function: metal ion binding; protein binding; protein heterodimerization activity; protein homodimerization activity; transcription corepressor activity. Biological Process: B cell differentiation; negative regulation of axon extension; negative regulation of collateral sprouting; negative regulation of protein homooligomerization; negative regulation of transcription from RNA polymerase II promoter; positive regulation of collateral sprouting; positive regulation of transcription from RNA polymerase II promoter; protein sumoylation; regulation of dendrite development; signal transduction; T cell differentiation; transcription from RNA polymerase II promoter

24-Strip-Wells

215 USD

48-Strip-Wells

410

96-Strip-Wells

490

5x96-Strip-Wells

2040

10x96-Strip-Wells

3590