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Human IGF-1 (Insulin-Like Growth Factor 1) CLIA Kit

MBS2532605

48-Strip-Wells

450 USD

CLIA Kit

Human IGF-1 (Insulin-Like Growth Factor 1) CLIA Kit

[IGF-1 (Insulin-Like Growth Factor 1)]

[IGF1; IGFI; IGF-I; IGF1A; IGF-IA; IGF-IB; MGF; Somatomedin C]

[insulin-like growth factor I preproprotein; Insulin-like growth factor I; insulin-like growth factor I; Somatomedin]

[IGF-1]

[IGF1; IGF1; IGF-1; IGF-I; IGF-I]

IGF1_BOVIN

Human

154

This kit recognizes Human PSA/KLK3 in samples. No significantcross-reactivity or interference between HumanPSA/KLK3 and analogues was observed.

Typical Testing Data/Standard Curve (for reference only)

Samples: Serum, Plasma And Other Biological Fluids. Assay Type: Quantitative Sandwich. Detection Range: 0.31-20ng/mL. Sensitivity: 0.19ng/mL.

Intended Uses: This CLIA kit applies to the in vitro quantitative determination of Human PSA/KLK3 concentrations in serum, plasma and other biological fluids. Principle of the Assay: This CLIA kit uses the Sandwich-CLIA principle. The micro CLIA plate provided in this kit has been pre-coated with an antibody specific to Human PSA/KLK3. Standards or samples are added to the micro CLIA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for Human PSA/KLK3 and Avidin-Horseradish Peroxidase (HRP) conjugate are added successively to each micro plate well and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Human PSA/KLK3, biotinylated detection antibody and Avidin-HRP conjugate will appear fluorescence. The Relative light unit (RLU) value is measured by the Chemiluminescence immunoassay analyzer. The RLU value is positively associated with the concentration of Human PSA/KLK3. You can calculate the concentration of Human PSA/KLK3 in the samples by comparing the RLU value of the samples to the standard curve.

118150782

NP_001071296.1

NM_001077828.1

17,066 Da

AMPK Signaling Pathway (989258); AMPK Signaling Pathway (992181); Adipogenesis Pathway (920913); Aldosterone-regulated Sodium Reabsorption Pathway (130625); Aldosterone-regulated Sodium Reabsorption Pathway (130590); Androgen Receptor Signaling Pathway (198553); Apoptosis Pathway (198572); Dilated Cardiomyopathy Pathway (121480); Dilated Cardiomyopathy Pathway (121285); Endochondral Ossification Pathway (920938)

The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca2+-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 ().

48-Strip-Wells

450 USD

96-Strip-Wells

535

5x96-Strip-Wells

2255

10x96-Strip-Wells

3975