Human IGFBP-1 (Insulin Like Growth Factor Binding Protein 1) CLIA Kit | MyBioSource MBS2531223 product information

product summary

company name :

MyBioSource

product type :

other

product name :

Human IGFBP-1 (Insulin Like Growth Factor Binding Protein 1) CLIA Kit

catalog :

MBS2531223

quantity :

48-Strip-Wells

price :

450 USD

more info or order :

MyBioSource product webpage

image

image 1 :

product information

catalog number :

MBS2531223

products type :

CLIA Kit

products full name :

Human IGFBP-1 (Insulin Like Growth Factor Binding Protein 1) CLIA Kit

products short name :

[IGFBP-1 (Insulin Like Growth Factor Binding Protein 1)]

products name syn :

[IGFBP1; AFBP; IBP1; IGF-BP25; PP12; placental protein 12]

other names :

[insulin-like growth factor-binding protein 1; Insulin-like growth factor-binding protein 1; insulin-like growth factor-binding protein 1; insulin-like growth factor binding protein 1; Placental protein 12; PP12]

products gene name :

[IGFBP-1]

other gene names :

[IGFBP1; IGFBP1; AFBP; IBP1; PP12; IGF-BP25; hIGFBP-1; IBP1; IBP-1; IGF-binding protein 1; IGFBP-1; PP12]

uniprot entry name :

IBP1_HUMAN

reactivity :

Human

sequence length :

259

specificity :

This kit recognizes natural and some recombinant Human IGFBP-1. No significant cross-reactivity or interference between Human IGFBP-1 and analogues was observed.

image1 heading :

Typical Testing Data/Standard Curve (for reference only)

other info1 :

Assay Type: Sandwich. Detection Range: 31.25-2000pg/mL. Sensitivity: Min: 18.75pg/mL; Max: 2000pg/mL

products description :

Intended Uses: This kit can be applied to the in vitro quantitative determination of Human IGFBP-1 concentrations in serum, plasma and other biological fluids. Principle of the Assay: This kit uses Sandwich-CLIA as the method. The micro CLIA plate provided in this kit has been pre-coated with an antibody specific to Human IGFBP-1. Standards or samples are added to appropriate micro CLIA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for Human IGFBP-1 and Avidin- Horseradish Peroxidase (HRP) conjugate are added to each micro plate well successively and incubated. After incubation, free components are washed away. Then the Substrate Reagent is added to each well, only those wells that contain Human IGFBP-1, biotinylated detection antibody and Avidin-HRP conjugate will appear fluorescence. The Relative light unit (RLU) value is measured spectrophotometrically by the Chemiluminescence immunoassay analyzer. The RLU value is positively associated with the concentration of Human IGFBP-1. The concentration of Human IGFBP-1 in samples can be calculated by comparing the RLU value of the samples to the standard curve.

ncbi gi num :

4504615

ncbi acc num :

NP_000587.1

ncbi gb acc num :

NM_000596.2

ncbi mol weight :

27,904 Da

ncbi pathways :

ATF4 Activates Genes Pathway (1268762); AhR Pathway (755436); FOXA2 And FOXA3 Transcription Factor Networks Pathway (137911); HIF-1-alpha Transcription Factor Network Pathway (138045); Metabolism Of Proteins Pathway (1268677); Myometrial Relaxation And Contraction Pathways (198759); PERK Regulates Gene Expression Pathway (1268761); Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway (1268755); Unfolded Protein Response (UPR) Pathway (1268756)

ncbi summary :

This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided by RefSeq, Jul 2008]

uniprot summary :

IGFBP1: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 7p12.3. Cellular Component: extracellular space; extracellular region. Molecular Function: insulin-like growth factor binding; insulin-like growth factor I binding; insulin-like growth factor II binding. Biological Process: regulation of insulin-like growth factor receptor signaling pathway; cellular protein metabolic process; unfolded protein response; tissue regeneration; insulin receptor signaling pathway; signal transduction; positive regulation of cell growth

size1 :

48-Strip-Wells

price1 :

450 USD

size2 :

96-Strip-Wells

price2 :

535

size3 :

5x96-Strip-Wells

price3 :

2255

size4 :

10x96-Strip-Wells

price4 :

3975

more info or order :

MyBioSource product webpage