Human TRF (Transferrin) CLIA Kit | MyBioSource MBS2530535 product information

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product summary

company name :

MyBioSource

product type :

other

product name :

Human TRF (Transferrin) CLIA Kit

catalog :

MBS2530535

quantity :

48-Strip-Wells

price :

450 USD

product information

catalog number :

MBS2530535

products type :

CLIA Kit

products full name :

Human TRF (Transferrin) CLIA Kit

products short name :

[TRF (Transferrin)]

products name syn :

[TF; PRO1557; PRO2086; TFQTL1; Siderophilin]

other names :

[transferrin; Serotransferrin; serotransferrin; transferrin; Beta-1 metal-binding globulin; Siderophilin]

products gene name :

[TRF]

other gene names :

[TF; TF; TFQTL1; PRO1557; PRO2086; Transferrin]

uniprot entry name :

TRFE_HUMAN

reactivity :

Human

sequence length :

698

specificity :

This kit recognizes natural and recombinant TRF. No significant cross-reactivity or interference between TRF and analogues was observed.

image1 heading :

Typical Testing Data/Standard Curve (for reference only)

other info1 :

Assay Type: Sandwich. Detection Range: 0.313-20ng/mL. Sensitivity: Min: 0.188ng/mL; Max: 20ng/mL

products description :

Intended Uses: This CLIA kit applies to the in vitro quantitative determination of TRF concentrations in serum, plasma and other biological fluids. Principle of the Assay This kit uses Sandwich-CLIA as the method. The micro CLIA plate provided in this kit has been pre-coated with an antibody specific to TRF. Standards or samples are added to the appropriate micro CLIA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for TRF and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain TRF, biotinylated detection antibody and Avidin-HRP conjugate will appear fluorescence. The Relative light unit (RLU) value is measured spectrophotometrically by the Chemiluminescence immunoassay analyzer. The RLU value is positively associated with the concentration of TRF. You can calculate the concentration of TRF in the samples by comparing the RLU value of the samples to the standard curve.

ncbi gi num :

339453

ncbi acc num :

AAA61140.1

ncbi mol weight :

77,064 Da

ncbi pathways :

EPHB Forward Signaling Pathway (138047); HIF-1 Signaling Pathway (695200); HIF-1-alpha Transcription Factor Network Pathway (138045); Hemostasis Pathway (1269340); Iron Metabolism In Placenta Pathway (672461); Iron Uptake And Transport Pathway (1269948); Mineral Absorption Pathway (212237); Mineral Absorption Pathway (212220); Platelet Activation, Signaling And Aggregation Pathway (1269350); Platelet Degranulation Pathway (1269367)

ncbi summary :

This gene encodes a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum. [provided by RefSeq, Sep 2009]

uniprot summary :

TF: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation. Defects in TF are the cause of atransferrinemia (ATRAF). Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia. Belongs to the transferrin family. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 3q22.1. Cellular Component: extracellular space; cell surface; cytoplasmic membrane-bound vesicle; early endosome; extracellular region; coated pit; recycling endosome; extrinsic to external side of plasma membrane; endocytic vesicle; perinuclear region of cytoplasm; late endosome; apical plasma membrane; basal plasma membrane; endosome membrane; vesicle. Molecular Function: protein binding; ferric iron binding; ferrous iron binding; ferric iron transmembrane transporter activity. Biological Process: platelet activation; retinal homeostasis; iron ion homeostasis; platelet degranulation; cellular iron ion homeostasis; transferrin transport; regulation of protein stability; blood coagulation; transmembrane transport; positive regulation of receptor-mediated endocytosis. Disease: Atransferrinemia

size1 :

48-Strip-Wells

price1 :

450 USD

size2 :

96-Strip-Wells

price2 :

535

size3 :

5x96-Strip-Wells

price3 :

2255

size4 :

10x96-Strip-Wells

price4 :

3975