FLI1 Antibody | MyBioSource MBS2530301 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

FLI1 Antibody

catalog :

MBS2530301

quantity :

0.06 mL

price :

195 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry

more info or order :

MyBioSource product webpage

image

image 1 :

Western Blot analysis of Hl-60 cells using FLI1 Polyclonal Antibody at dilution of 1:1000

image 2 :

Immunohystochemistry of paraffin-embedded human lymphoma tissue using FL11 Polyclonal Antibody at dilution of 1:200(under 40x lens).

product information

catalog number :

MBS2530301

products type :

Antibody

products full name :

FLI1 Antibody

products short name :

[FLI1]

products name syn :

[EWSR2, FLI1, Proto oncogene Fli 1, SIC 1, Transcription factor ERGB.]

other names :

[Friend leukemia integration 1 transcription factor isoform 4; Friend leukemia integration 1 transcription factor; Friend leukemia integration 1 transcription factor; Ewing sarcoma breakpoint region 2; Friend leukemia virus integration 1; transcription factor ERGB; Fli-1 proto-oncogene, ETS transcription factor; Proto-oncogene Fli-1; Transcription factor ERGB]

products gene name :

[FLI1]

other gene names :

[FLI1; FLI1; EWSR2; SIC-1]

uniprot entry name :

FLI1_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse

sequence length :

259

purity :

Affinity purification

form :

PBS with 0.1% sodium azide, 50% glycerol, pH7.3

storage stability :

Store at -20 degree C. Avoid freeze / thaw cycles

tested application :

Western Blot (WB), Immunohistochemistry (IHC), ELISA

app notes :

WB: 1:500-1:2000, IHC: 1:50-1:200

image1 heading :

Western Blot WB

image2 heading :

Immunohistochemistry IHC

other info1 :

Immunogen: Fusion protein of FLI1

other info2 :

Note: Centrifuge before opening to ensure complete recovery of vial contents.

products description :

Friend leukemia virus integration 1 (FLI1) that is also termed EWSR2 encodes a sequence-specific transcriptional activator involved in Ewing's sarcoma (EWS),a malignant small, round, blue cell tumour. It is a rare disease in which cancer tells are found in the bone or in soft tissue. The most common areas in which it occurs are the pelvis,the femur, the humerus, the ribs and clavicle. And EWS occurs most frequently in teenagers and young adults. FLI1 protein mau act as an aberrant transcription factor, but exact mechanisms of oncogenesis remains unknown.

ncbi gi num :

401871078

ncbi acc num :

BC010115

ncbi gb acc num :

NM_001271012.1

uniprot acc num :

Q01543

ncbi mol weight :

Calculated MW: 452aa,51 kDa. Observed MW: 51 kDa

ncbi pathways :

Transcriptional Misregulation In Cancer Pathway (523016); Transcriptional Misregulation In Cancer Pathway (522987)

ncbi summary :

This gene encodes a transcription factor containing an ETS DNA-binding domain. The gene can undergo a t(11;22)(q24;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases. An acute lymphoblastic leukemia-associated t(4;11)(q21;q23) translocation involving this gene has also been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

uniprot summary :

FLI1: Sequence-specific transcriptional activator. Recognizes the DNA sequence 5 -C[CA]GGAAGT-3 . Defects in FLI1 are a cause of Ewing sarcoma (ES). A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors. A chromosomal aberration involving FLI1 is found in patients with Erwing sarcoma. Translocation t(11;22)(q24;q12) with EWSR1. Belongs to the ETS family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Transcription factor; Oncoprotein; DNA-binding. Chromosomal Location of Human Ortholog: 11q24.1-q24.3. Cellular Component: nucleus. Molecular Function: DNA binding; chromatin binding; transcription factor activity. Biological Process: transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; organ morphogenesis; hemostasis; blood circulation; positive regulation of transcription from RNA polymerase II promoter; cell differentiation

size1 :

0.06 mL

price1 :

195 USD

size2 :

0.12 mL

price2 :

270

size3 :

0.2 mL

price3 :

435

more info or order :

MyBioSource product webpage