CD24 Antibody | MyBioSource MBS2530286 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

CD24 Antibody

catalog :

MBS2530286

quantity :

0.06 mL

price :

195 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS2530286

products type :

Antibody

products full name :

CD24 Antibody

products short name :

CD24

products name syn :

CD24A; FLJ22950; FLJ43543; MGC75043

other names :

CD24; Signal transducer CD24; signal transducer CD24; CD24 antigen (small cell lung carcinoma cluster 4 antigen); CD24 molecule; Small cell lung carcinoma cluster 4 antigen; CD_antigen: CD24

products gene name :

CD24

other gene names :

CD24; CD24; CD24A; CD24A

uniprot entry name :

CD24_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

purity :

Antigen affinity purification

storage stability :

Store at -20 degree C. Avoid freeze / thaw cycles

tested application :

ELISA (EIA), Western Blot (WB)

app notes :

WB: 1:200-1:2000

products description :

Background/Introduction: CD24 (known as heat stable antigen) is a small highly glycosylated GPI-linked sialoprotein. It is normally expressed at the surface of most B lymphocytes and differentiating neuroblasts, and it is also up-regulated in a wide variety of cancers. Studies have shown that CD24 functions in the regulation of B-cell apoptosis, leukocyte signal transduction, and leukocyte adhesion. Since it is highly glycosylated, the apparent molecular weight of CD24 could be variable, ranging from 30 kDa to 70 kDa.

ncbi gi num :

209405388

ncbi acc num :

ACI46150.1

ncbi pathways :

Axon Guidance Pathway (105688); Developmental Biology Pathway (477129); Hematopoietic Cell Lineage Pathway (83078); Hematopoietic Cell Lineage Pathway (489); L1CAM Interactions Pathway (161003)

ncbi summary :

This gene encodes a sialoglycoprotein that is expressed on mature granulocytes and B cells and modulates growth and differentiation signals to these cells. The precursor protein is cleaved to a short 32 amino acid mature peptide which is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell surface. This gene was missing from previous genome assemblies, but is properly located on chromosome 6. Non-transcribed pseudogenes have been designated on chromosomes 1, 15, 20, and Y. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

uniprot summary :

CD24: Modulates B-cell activation responses. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells. Genetic variations in CD24 are associated with susceptibility to multiple sclerosis (MS). A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheat, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease. Polymorphisms in CD24 may act as a genetic modifier for susceptibility and progression of MS in some populations, perhaps by affecting the efficiency of CD24 expression on the cell surface. Belongs to the CD24 family. Protein type: Membrane protein, GPI anchor; Motility/polarity/chemotaxis; Cell surface; Cell development/differentiation. Chromosomal Location of Human Ortholog: 6q21. Cellular Component: cell surface; membrane; plasma membrane; lipid raft. Molecular Function: signal transducer activity; protein binding; protein tyrosine kinase activator activity; protein kinase binding. Biological Process: respiratory burst; axon guidance; cell migration; Wnt receptor signaling pathway; regulation of phosphorylation; B cell receptor transport into lipid raft; immune response-regulating cell surface receptor signaling pathway; chemokine receptor transport out of lipid raft; positive regulation of activated T cell proliferation; positive regulation of MAP kinase activity; cell activation; cell-cell adhesion; cholesterol homeostasis; elevation of cytosolic calcium ion concentration; response to estrogen stimulus; response to molecule of bacterial origin; regulation of MAPKKK cascade; T cell costimulation; negative regulation of transforming growth factor-beta3 production; regulation of epithelial cell differentiation; response to hypoxia; regulation of cytokine and chemokine mediated signaling pathway. Disease: Multiple Sclerosis, Susceptibility To

size1 :

0.06 mL

price1 :

195 USD

size2 :

0.12 mL

price2 :

270

size3 :

0.2 mL

price3 :

435

more info or order :

MyBioSource product webpage