product summary
request information :
company name :
MyBioSource
product type :
protein
product name :
N-acetylgalactosamine-6-sulfatase
catalog :
MBS253012
quantity :
0.01 mg
price :
285 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS253012
products type :
Recombinant Protein
products full name :
N-acetylgalactosamine-6-sulfatase
products short name :
N-acetylgalactosamine-6-sulfatase
other names :
N-acetylgalactosamine-6-sulfatase; N-acetylgalactosamine-6-sulfatase; N-acetylgalactosamine-6-sulfatase; chondroitinase; galNAc6S sulfatase; chondroitinsulfatase; galactose-6-sulfate sulfatase; N-acetylgalactosamine-6-sulfate sulfatase; galactosamine (N-acetyl)-6-sulfate sulfatase; galactosamine (N-acetyl)-6-sulfatase; Chondroitinsulfatase; Chondroitinase; Galactose-6-sulfate sulfatase; GalN6S; N-acetylgalactosamine-6-sulfate sulfatase; GalNAc6S sulfatase
other gene names :
GALNS; GALNS; GAS; MPS4A; GalN6S; GALNAC6S; Chondroitinase; GalN6S; GalNAc6S sulfatase
uniprot entry name :
GALNS_HUMAN
host :
Yeast
sequence length :
522
sequence :
APQPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAE
GLLFPNFYSANPLCSPSRAALLTGRLPIRNGFYTTNAHA
RNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHL
GHRPQFHPLKHGFDEWFGSPNCHFGPYDNKARPNIPVYR
DWEMVGRYYEEFPINLKTGEANLTQIYLQEALDFIKRQA
RHHPFFLYWAVDATHAPVYASKPFLGTSQRGRYGDAVRE
IDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQ
GGSNGPFLCGKQTTFEGGMREPALAWWPGHVTAGQVSHQ
LGSIMDLFTTSLALAGLTPPSDRAIDGLNLLPTLLQGRL
MDRPIFYYRGDTLMAATLGQHKAHFWTWTNSWENFRQGI
DFCPGQNVSGVTTHNLEDHTKLPLIFHLGRDPGERFPLS
FASAEYQEALSRITSVVQQHQEALVPAQPQLNVCNWAVM
NWAPPGCEKLGKCLTPPESIPKKCLWSH
purity :
>90%(SDS-PAGE)
storage stability :
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C. Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
other info1 :
Tag Information: His tagged. Relevance: We cloned and sequenced a full-length cDNA of human placental N-acetylgalactosamine-6-sulfate sulfatase, the enzyme deficient in Morquio disease. The 2339-nucleotide sequence contained 1566 nucleotides which encoded a polypeptide of 522 amino acid residues. The deduced amino acid sequence was composed of a 26-amino acid N-terminal signal peptide and a mature polypeptide of 496 amino acid residues including two potenital asparagine-linked glycosylation sites. Expression of the cDNA in transfected deficient fibroblasts. The cDNA clone was hybridized to only a 2.3-kilobase species of RNA in human fibroblasts.
other info2 :
Organism: Homo sapiens (Human). Storage Buffer: 20mM Tris-HCI, 0.5M NaCI, PH 8.0, 50% glycerol
ncbi gi num :
4503899
ncbi acc num :
NP_000503.1
ncbi gb acc num :
NM_000512.4
ncbi mol weight :
56kD
ncbi pathways :
Chondroitin Sulfate Degradation Pathway 413376!!Chondroitin Sulfate Degradation Pathway 468247!!Glycosaminoglycan Degradation Pathway 82981!!Glycosaminoglycan Degradation Pathway 355!!Keratan Sulfate Degradation Pathway 413378!!Keratan Sulfate Degradation Pathway 468269!!Lysosome Pathway 99052!!Lysosome Pathway 96865!!Metabolic Pathways 132956
ncbi summary :
This gene encodes N-acetylgalactosamine-6-sulfatase which is a lysosomal exohydrolase required for the degradation of the glycosaminoglycans, keratan sulfate, and chondroitin 6-sulfate. Sequence alterations including point, missense and nonsense mutations, as well as those that affect splicing, result in a deficiency of this enzyme. Deficiencies of this enzyme lead to Morquio A syndrome, a lysosomal storage disorder. [provided by RefSeq, Jul 2008]
size :
0.01 mg
price :
285 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
www.mybiosource.com
1-888-627-0165
headquarters: USA
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