product summary
Loading...
company name :
MyBioSource
product type :
antibody
product name :
INVS Antibody
catalog :
MBS2530068
quantity :
0.06 mL
price :
195 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay
more info or order :
image
image 1 :
MCF7 cells were subjected to SDS PAGE followed by western blot with INVS antibody at dilution of 1 : 100
image 2 :
Immunohistochemical of paraffin-embedded human breast cancer using INVS antibody at dilution of 1:100
image 3 :
Immunofluorescent analysis ofHela
celis, using INVS antibody at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
product information
catalog number :
MBS2530068
products type :
Antibody
products full name :
INVS Antibody
products short name :
[INVS]
products name syn :
[INV; KIAA0573; MGC133080; MGC133081; NPH2; NPHP2]
other names :
[inversin isoform a; Inversin; inversin; inversion of embryo turning homolog; inversion of embryonic turning; nephrocystin-2; inversin; Inversion of embryo turning homolog; Nephrocystin-2]
products gene name :
[INVS]
other gene names :
[INVS; INVS; INV; NPH2; NPHP2; INV; NPHP2]
uniprot entry name :
INVS_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human, Mouse, Rat
sequence length :
1065
purity :
Antigen affinity purification
storage stability :
Store at -20 degree C. Avoid freeze / thaw cycles
tested application :
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
app notes :
WB: 1:200-1:1000. IHC: 1:20-1:200. IF: 1:10-1:100
image1 heading :
Testing Data
image2 heading :
Immunohistochemistry
image3 heading :
Immunofluorescence
other info1 :
Immunogen: Fusion protein of INVS. Calculated Molecular Weight: 118kd; 100kd. Observed Molecular Weight: 110-115kd
other info2 :
Buffer: PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-8719 / sc-12550
ncbi gi num :
34304381
ncbi acc num :
NP_055240.2
ncbi gb acc num :
NM_014425.3
ncbi mol weight :
10,748 Da
ncbi summary :
This gene encodes a protein containing multiple ankyrin domains and two IQ calmodulin-binding domains. The encoded protein may function in renal tubular development and function, and in left-right axis determination. This protein interacts with nephrocystin and infers a connection between primary cilia function and left-right axis determination. A similar protein in mice interacts with calmodulin. Mutations in this gene have been associated with nephronophthisis type 2. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, May 2012]
uniprot summary :
INVS: Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. Involved in the organization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8. Does not seem to be strictly required for ciliogenesis. Defects in INVS are the cause of nephronophthisis type 2 (NPHP2); also known as infantile nephronophthisis. NPHP2 is an autosomal recessive disorder resulting in end-stage renal disease. It is characterized by early onset and rapid progression. Phenotypic manifestations include enlarged kidneys, chronic tubulo-interstitial nephritis, anemia, hyperkalemic metabolic acidosis. Some patients also display situs inversus. Pathologically, it differs from later-onset nephronophthisis by the absence of medullary cysts and thickened tubular basement membranes and by the presence of cortical microcysts. 3 isoforms of the human protein are produced by alternative splicing. Chromosomal Location of Human Ortholog: 9q31. Cellular Component: microtubule; membrane; cytoplasm; spindle; nucleus. Molecular Function: calmodulin binding; protein binding. Biological Process: Wnt receptor signaling pathway; pancreas development; kidney development; post-embryonic development. Disease: Nephronophthisis 2
size1 :
0.06 mL
price1 :
195 USD
size2 :
0.12 mL
price2 :
270
size3 :
0.2 mL
price3 :
435
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
"MyBioSource offers the best products at unbeatable prices."
Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.
Would you like to receive email and e-newsletter from MyBioSource about new products, special offers and events? Please click here to join our Mailing List!