IRF5 Antibody | MyBioSource MBS2529606 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

IRF5 Antibody

catalog :

MBS2529606

quantity :

0.06 mL

price :

150 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of extracts of various cell lines, using IRF5 antibody.

image 2 :

Immunofluorescence analysis of HeLa cell using IRF5 antibody. Blue: DAPI for nuclear staining.

product information

catalog number :

MBS2529606

products type :

Antibody

products full name :

IRF5 Antibody

products short name :

[IRF5]

products name syn :

[IRF5; SLEB10]

other names :

[interferon regulatory factor 5 isoform e; Interferon regulatory factor 5; interferon regulatory factor 5; interferon regulatory factor 5]

products gene name :

[IRF5]

other gene names :

[IRF5; IRF5; SLEB10; IRF-5]

uniprot entry name :

IRF5_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

412

purity :

Affinity purification

concentration :

1mg/mL

storage stability :

Store at -20 degree C, Avoid freeze / thaw cycles

tested application :

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

app notes :

WB: 1:500-1:2000,IHC: 1:50-1:200,IF :1:50-1:200

image1 heading :

Western Blot (WB)

image2 heading :

Immunofluorescence (IF)

other info2 :

Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-98651

products description :

Background/Introduction: Interferon regulatory factors (IRFs) comprise a family of transcription factors that function within the Jak/Stat pathway to regulate interferon (IFN) and IFN-inducible gene expression in response to viral infection (1). IRFs play an important role in pathogen defense, autoimmunity, lymphocyte development, cell growth, and susceptibility to transformation. The IRF family includes nine members: IRF-1, IRF-2, ISGF3gamma/p48, IRF-3, IRF-4 (Pip/LSIRF/ICSAT), IRF-5, IRF-6, IRF-7, and IRF-8/ICSBP. All IRF proteins share homology in their amino-terminal DNA-binding domains. IRF family members regulate transcription through interactions with proteins that share similar DNA-binding motifs, such as IFN-stimulated response elements (ISRE), IFN consensus sequences (ICS), and IFN regulatory elements (IRF-E) (2).IRF-5 is expressed in lymphoid tissues and peripheral blood lymphocytes and participates in the induction of type I interferon genes following viral infection (3). Activation of IRF-5 signaling is triggered by the toll-like receptor (TLR) pathway, including TLR7 and MyD88 (4,5). Genetic variants of IRF-5 have been associated with disorders where the IFN pathway is abnormally activated, such as systemic lupus erythematosus (6,7).

ncbi gi num :

334883190

ncbi acc num :

NP_001229381.1

ncbi gb acc num :

NM_001242452.2

ncbi mol weight :

56kDa

ncbi pathways :

Apoptosis Pathway (198797); Cytokine Signaling In Immune System Pathway (366171); Direct P53 Effectors Pathway (137939); Immune System Pathway (106386); Interferon Signaling Pathway (187103); Interferon Alpha/beta Signaling Pathway (187104); Interferon Gamma Signaling Pathway (187106); Regulation Of Toll-like Receptor Signaling Pathway (920955); Senescence And Autophagy Pathway (198780); Toll-like Receptor Signaling Pathway (83076)

ncbi summary :

This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Multiple transcript variants encoding different isoforms have been found for this gene, and a 30-nt indel polymorphism (SNP rs60344245) can result in loss of a 10-aa segment. [provided by RefSeq, Mar 2010]

uniprot summary :

IRF5: Transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection. Activated by TLR7 or TLR8 signaling. Homodimer, when phosphorylated. Belongs to the IRF family. 4 isoforms of the human protein are produced by alternative splicing. Protein type: DNA-binding; Transcription factor. Chromosomal Location of Human Ortholog: 7q32. Cellular Component: cytoplasm; cytosol; nucleus. Molecular Function: protein binding; transcription factor activity. Biological Process: transcription, DNA-dependent; positive regulation of interleukin-12 production; positive regulation of apoptosis; response to muramyl dipeptide; cytokine and chemokine mediated signaling pathway; response to peptidoglycan; positive regulation of interferon-beta production; positive regulation of transcription from RNA polymerase II promoter; defense response to virus; positive regulation of interferon-alpha production. Disease: Systemic Lupus Erythematosus, Susceptibility To, 10; Inflammatory Bowel Disease 14

size1 :

0.06 mL

price1 :

150 USD

size2 :

0.12 mL

price2 :

225

size3 :

0.2 mL

price3 :

360

more info or order :

MyBioSource product webpage