LILRB2 Polyclonal Antibody | MyBioSource MBS2529359 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

LILRB2 Polyclonal Antibody

catalog :

MBS2529359

quantity :

0.02 mL

price :

110 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using LILRB2 Polyclonal Antibody at dilution 1:30

image 2 :

Immunohistochemistry of paraffin-embedded Human cervical cancer tissue using LILRB2 Polyclonal Antibody at dilution 1:30

product information

catalog number :

MBS2529359

products type :

Antibody

products full name :

LILRB2 Polyclonal Antibody

products short name :

[LILRB2]

products name syn :

[ILT4, LIR2, CD85D, LIR-2, MIR10, LILRA6, MIR-10]

other names :

[leukocyte immunoglobulin-like receptor subfamily B member 2 isoform 5; Leukocyte immunoglobulin-like receptor subfamily B member 2; leukocyte immunoglobulin-like receptor subfamily B member 2; CD85 antigen-like family member D; Ig-like transcript 4; monocyte/macrophage immunoglobulin-like receptor 10; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2; CD85 antigen-like family member D; Immunoglobulin-like transcript 4; ILT-4; Monocyte/macrophage immunoglobulin-like receptor 10; MIR-10; CD_antigen: CD85d]

products gene name :

[LILRB2]

other gene names :

[LILRB2; LILRB2; ILT4; LIR2; CD85D; ILT-4; LIR-2; MIR10; MIR-10; ILT4; LIR2; MIR10; LIR-2; Leukocyte immunoglobulin-like receptor 2; ILT-4; MIR-10]

uniprot entry name :

LIRB2_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human

sequence length :

455

purity :

Affinity purification

storage stability :

Store at -20°C. Avoid freeze / thaw cycles.

tested application :

ELISA (EIA), Immunohistochemistry (IHC)

app notes :

IHC: 1:25-1:100

image1 heading :

Immunohistochemistry (IHC)

image2 heading :

Immunohistochemistry (IHC)

other info1 :

Immunogen: Recombinant protein of human LILRB2

other info2 :

Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3

products description :

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13. 4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.

ncbi gi num :

618857478

ncbi acc num :

NP_001265335.2

ncbi gb acc num :

NM_001278406.2

uniprot acc num :

BC036827

ncbi pathways :

Adaptive Immune System Pathway (366160); Immune System Pathway (106386); Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway (106413); Osteoclast Differentiation Pathway (193147); Osteoclast Differentiation Pathway (193096)

ncbi summary :

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

LILRB2: Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 19q13.4. Cellular Component: extracellular space; cell surface; membrane; integral to plasma membrane; cytoplasm; plasma membrane. Molecular Function: protein binding; MHC class I protein binding; cell adhesion molecule binding; receptor activity; protein phosphatase 1 binding; inhibitory MHC class I receptor activity. Biological Process: immune response-inhibiting cell surface receptor signaling pathway; negative regulation of calcium ion transport; regulation of immune response; positive regulation of regulatory T cell differentiation; negative regulation of immune response; positive regulation of interleukin-6 production; signal transduction; positive regulation of tolerance induction; heterotypic cell-cell adhesion; negative regulation of T cell proliferation; cell surface receptor linked signal transduction; cell-cell signaling; negative regulation of antigen processing and presentation; cellular defense response; Fc receptor mediated inhibitory signaling pathway; immune response; positive regulation of T cell proliferation; positive regulation of T cell tolerance induction

size1 :

0.02 mL

price1 :

110 USD

size2 :

0.06 mL

price2 :

150

size3 :

0.12 mL

price3 :

225

size4 :

0.2 mL

price4 :

360

more info or order :

MyBioSource product webpage